Wobenzym is a combination drug that contains highly active enzymes of animal and plant origin.
It has anti-inflammatory, immunomodulatory, secondary analgesic, antiplatelet and fibrinolytic effects.
In this article, we will look at why doctors prescribe Wobenzym, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Wobenzym can be read in the comments.
Composition and form of release
Wobenzym is produced in the form of coated tablets of 40 or 200 pieces in packs and 800 pieces in high-density polyethylene bottles.
- One Wobenzym tablet contains the following active ingredients: 100 mg of pancreatin, 60 mg of papain, 50 mg of rutin, 45 mg of bromelain, 24 mg of chymotrypsin, 10 mg of amylase, 10 mg of lipase, 1 mg of chymotrypsin
Clinico-pharmacological group: a drug with anti-inflammatory and immunomodulatory effects.
What helps Wobenzym?
Wobenzym is prescribed to patients for the treatment and prevention of the following conditions:
- In cardiology - for the treatment of coronary heart disease, as well as to mitigate the consequences of myocardial infarction;
- In gastroenterology - for the treatment of pancreatitis, ulcerative colitis, etc.;
- In endocrinology - for the treatment of diabetic angiopathy, retinopathy, autoimmune thyroiditis, etc.;
- In dermatology - for patients with acne or atopic dermatitis;
- In nephrology - for the treatment of pyelonephritis and glomerulonephritis;
- In pulmonology - for the treatment of diseases affecting the upper and lower respiratory tract;
- In rheumatology - for the treatment of rheumatoid arthritis, extra-articular rheumatism, ankylosing spondylitis, Sjögren's syndrome, etc.;
- In urology - to eliminate inflammatory diseases of the genitourinary system, cystitis, cystopyelitis, prostatitis, etc.;
- In surgical practice - for the treatment and prevention of the development of various kinds of postoperative complications, for the prevention of adhesions, the appearance of post-traumatic edema, etc.;
- In traumatology - with dislocations, fractures, bruises, sprains, chronic post-traumatic processes, sports injuries, etc.;
- In angiology - for the treatment of diseases of the vessels of the circulatory and lymphatic systems: thrombophlebitis, vasculitis, phlebitis, lymphedema, post-thrombotic syndrome, etc.;
- In neurology - with multiple sclerosis.
Additionally, indications for Wobenzym include the prevention of the following conditions:
- acclimatization and adaptation;
- microcirculation disorders;
- post-stress disorders;
- vascular accidents;
- negative phenomena during hormone therapy;
- viral infections or their subsequent complications;
- dysbiotic disorders during antibiotic therapy.
pharmachologic effect
Wobenzym is a combination of natural plant and animal enzymes. Entering the body, enzymes are absorbed in the small intestine by resorption of intact molecules and, by binding to blood transport proteins, enter the bloodstream.
In the future, enzymes, migrating along the vascular bed and accumulating in the area of the pathological process, have an immunomodulatory, anti-inflammatory, fibrinolytic, anti-edematous, antiplatelet and secondary analgesic effect.
The active components of Wobenzym accelerate the resorption of hematomas and eliminate edema, normalize the permeability of the walls of blood vessels, as well as the rheological functions of the blood. Under the influence of the enzymes included in the tablet, the internal organs and tissues of the body are better supplied with oxygen and nutrients, which increases their performance and eliminates disorders.
In addition to all this, the components that make up the drug have the following effect on the patient's body:
- Increase the concentration of antibiotics in the focus of inflammation, but at the same time reduce the risk of side effects;
- Reduce the level of cholesterol in the blood and the risk of atherosclerosis;
- Stimulate the production of interferon;
- Accelerate the elimination of toxins from the body;
- Normalize fat metabolism.
Instructions for use
According to the instructions for use, Wobenzym tablets are taken orally with plenty of liquid, half an hour before meals. In the first three days from the beginning of the therapeutic course, three tablets are prescribed three times a day, then, depending on the severity of the disease, three to ten tablets are taken three times a day.
A detailed treatment regimen and an adequate dosage are selected by a specialist individually for each patient.
- Adults, depending on the activity and severity of the disease, are prescribed in a dose of 3 to 10 tablets. 3 times / day. In the first 3 days of taking the drug, the recommended dose is 3 tab. 3 times / day.
- With an average activity of the disease, the drug is prescribed in a dose of 5-7 tab. 3 times / day for 2 weeks. In the future, the dose of the drug should be reduced to 3-5 tab. 3 times / day. Course - 2 weeks.
- With high disease activity, the drug is prescribed in a dose of 7-10 tab. 3 times / day for 2-3 weeks. In the future, the dose should be reduced to 5 tab. 3 times / day. Course - 2-3 months.
Use in various diseases and conditions:
- As a "cover" therapy during chemotherapy and radiation therapy to improve tolerance, prevent infectious complications and improve the quality of life, Wobenzym is prescribed 5 tablets 3 times a day until the end of the course of treatment. In the future, to restore immunity, the drug is taken for 21 days 3 times a day, 3 tablets.
- In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, Wobenzym should be used throughout the course of antibiotic therapy at a dose of 5 tab. 3 times / day. After stopping the course of antibiotic therapy to restore the intestinal microflora, Wobenzym should be prescribed 3 tab. 3 times / day for 2 weeks.
- With a preventive goal to increase resistance to diseases, the threshold of adaptation and reduce the risk of vascular accidents and diseases, Wobenzym is recommended to be taken in a course of 3-6 weeks, 2-3 tablets 3 times a day. The course can be repeated 2-3 times a year.
In pediatric practice, the drug is prescribed to children over 5 years of age in order to strengthen the body's defenses or as part of complex therapy for various infections. Children from 5 to 12 years old, according to the instructions, are prescribed 3-5 tablets 3 times a day. For children over 12 years of age, the daily dose of the drug is calculated as for adults.
Contraindications
The drug "Wobenzym" instructions for use prohibits taking with:
- Individual intolerance to the composition.
- Hemophilia.
- thrombocytopenia.
Caution during treatment should be observed in pregnant women. Despite the fact that Wobenzym is not an antibiotic, its action increases the concentration of the active substances of these drugs in the area of inflammation and blood plasma.
Side effects
If the regimen is followed, side effects are rare.
- In some cases, there were observed: vomiting, nausea, heaviness in the stomach, diarrhea, changes in the smell and consistency of feces, allergies to some components of the drug, skin rashes. With the abolition of Wobenzym or a decrease in the dose, all adverse reactions disappear.
There was no addiction and withdrawal syndrome, even with prolonged treatment with high doses.
Analogues
The most famous analogues of the drug are: Anaferon, Broncho-Vaxom, Galavit, Immunal, Imudon, Wobenzym, Neuroferon, Ribomunil, Cycloferon, Engystol.
Prices
The average price of WOBENZIM in pharmacies (Moscow) is 500 rubles.
Holiday conditions
The drug Wobenzym is dispensed in pharmacies without a doctor's prescription.
Tablets, a combination of highly active enzymes of animal and vegetable origin. Wobenzym has a secondary analgesic, anti-inflammatory, immunomodulatory, fibrinolytic, decongestant, antiplatelet, antiviral and antimicrobial action.
With a deficiency of enzymes in the body, the risk of acute and chronic diseases increases. Wobenzym increases the concentration of antibiotics in the body, enhances their action, preventing possible complications.
Wobenzym promotes the removal of toxic metabolic products, dying tissues, improves the permeability of the walls of blood vessels, accelerates the resorption of edema and hematomas. Wobenzym tablets have a beneficial effect on the state of the blood: it normalizes its viscosity, improves microcirculation, restores the mobility of red blood cells, saturates the tissue with oxygen and nutrients. When using hormonal agents, Wobenzym helps to reduce the risk of side effects.
Wobenzym is produced in the form of tablets (pellets) and is used in the following areas of medicine:
- cardiology,
- dermatology,
- endocrinology,
- nephrology,
- neurology,
- gynecology,
- urology,
- surgery,
- traumatology,
- rheumatology,
- angiology,
- pulmonology,
- gastroenterology.
Each Wobenzym package contains 40, 200 or 800 red-orange dragees coated with a smooth shell.
Anatomical Therapeutic Chemical Classification (ATC)
Anatomical-therapeutic-chemical classification (anatomical-therapeutic-chemical, ATC)– international classification system for medicines. The main purpose of ATC is to provide statistical data on the consumption of medicines.
According to the ATC, the drug Wobenzym in tablets belongs to the section "L03AX Other immunostimulants".
Clinical and pharmacological group
Wobenzym belongs to the clinical and pharmacological group of drugs with anti-inflammatory and immunomodulatory effects.
Nosological classification (ICD-10)
The Tenth Revision International Classification of Diseases (ICD-10) is a standard assessment tool in the field of health management, medicine, epidemiology, and analysis of the general health of the population. According to ICD-10, Wobenzym tablets can be used for the following diseases and conditions:
The term "specified" disease (condition) is used in cases where the doctor has a complete package of medical documents that allow the most objective assessment of the development of the disease (condition). In a situation where this set of documents is missing, and it is impossible to determine the course of the disease by the state of the internal organs, a diagnosis is made. unspecified».
Composition
One Wobenzym tablet contains 250 milligrams of proteolytic enzymes from papaya and pineapple plants, animal pancreas: rutin, pancreatin, bromelain, trypsin, papain, amylase, chymotrypsin and lipase.
Wobenzym contains the following excipients:
- lactose monohydrate,
- purified water,
- corn starch,
- talc,
- stearic acid,
- sucrose,
- magnesium stearate,
- silicon dioxide, highly dispersed,
- calcium carbonate,
- copolymer of methyl methacrylate and methacrylic acid,
- resin,
- titanium dioxide,
- white, yellow-orange and crimson dyes,
- macrogol 6000,
- povidone,
- vanillin,
- triethylcitrate,
- carnauba wax,
- bleached wax.
Instructions for use Wobenzym
Wobenzym is taken on an empty stomach, 30 minutes before eating, washed down with 200 milliliters of water. Wobenzym is prescribed by a doctor depending on the severity of the disease. At the initial stage of treatment, the recommended dose is five to ten tablets three times a day for 14-21 days. In chronic diseases, the course of treatment continues up to six months or more. With the parallel use of antibiotics, Wobenzym is prescribed for use five tablets three times a day. For prophylaxis, the drug, according to the instructions, lasts 45 days, three tablets three times a day. The course of application is repeated two or three times during the year.
Wobenzym during pregnancy
Wobenzym is not contraindicated for use during pregnancy and lactation. The drug is recommended for use as an integral part of the complex therapy of miscarriage starting from the second trimester of pregnancy. The duration of use of Wobenzym and its dosage are agreed with a medical specialist.
Trade name of the drug: WOBENZIM (WOBENZYM ®)
Dosage form: enteric-coated tablets (pellets).
Composition:
Active substances:
Pancreatin 345 prot. Evr.Pharm.-U, papain 90 FIP-U, rutoside 3 H 2 O 50.00 mg, bromelain 225 FIP-U, trypsin 360 FIP-U. lipase 34 FIP-U. amylase 50 FIP- Unit, chymotrypsin 300 FIP-Unit
Excipients:
Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc.
Sucrose, talc, methacrylic acid-methyl methacrylate copolymer, shellac, titanium dioxide, white clay, yellow-orange dye S (E110), crimson dye 4R (E124), povidone, macrogol 6000, triethyl citrate, vanillin, bleached wax, carnauba wax.
Description: Round biconvex tablets with a smooth surface, with a characteristic odor, painted in red-orange color. Fluctuations in the color intensity of the outer shell from red-orange to red are allowed.
Pharmacotherapeutic group: anti-inflammatory, immunomodulatory agent.
ATX code E03AX
Pharmacological properties
WOBENZYM is a combination of natural plant and animal enzymes. Entering the body, enzymes are absorbed in the small intestine by resorption of intact molecules and, by binding to blood transport proteins, enter the bloodstream. In the future, enzymes, migrating along the vascular bed and accumulating in the area of the pathological process, have an immunomodulatory, anti-inflammatory, fibrinolytic, anti-edematous, antiplatelet and secondary analgesic effect.
WOBENZYM has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, and positively affects the parameters of the body's immunological reactivity. It stimulates and regulates the level of functional activity of monocytes-macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.
Under the influence of WOBENZYMA, the number of circulating immune complexes decreases and the membrane deposits of immune complexes are removed from tissues.
WOBENZIM reduces the infiltration of the interstitium by plasma cells. Increases the elimination of protein detritus and fibrin deposits in the area of inflammation, accelerates the lysis of toxic metabolic products and necrotic tissues. Improves resorption of hematomas and edema, normalizes the permeability of vessel walls.
WOBENZIM reduces the concentration of thromboxane and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of erythrocytes to change their shape by regulating their plasticity, normalizes the number of normal discocytes and reduces the total number of activated forms of platelets, normalizes blood viscosity, reduces the total number of microaggregates, thus improving microcirculation and rheological properties of blood, as well as tissue supply oxygen and nutrients.
WOBENZIM reduces the severity of side effects associated with the use of hormonal drugs (hypercoagulation, etc.).
WOBENZYM normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the content of high-density lipoproteins, reduces the level of atherogenic lipids, and improves the absorption of polyunsaturated fatty acids.
WOBENZYME increases the concentration of antibiotics in the blood plasma and inflammation, thus increasing the effectiveness of their use. At the same time, enzymes reduce unwanted side effects of antibiotic therapy (dysbacteriosis), by improving the environment.
WOBENZYM regulates nonspecific defense mechanisms (production of interferons), thereby exhibiting antiviral and antimicrobial effects.
Indications for use
Applies in complex therapy the following diseases:
| Angiology: | thrombophlebitis, treatment of post-thrombophlebitic disease and acute thrombophlebitis of superficial veins, endarteritis and obliterating atherosclerosis of arteries of the lower extremities, prevention of recurrent phlebitis, lymphedema. |
| Urology: | cystitis, cystopyelitis, prostatitis, sexually transmitted infections. |
| Gynecology: | chronic infections of the genitals, adnexitis, gestosis, mastopathy, to reduce the frequency and severity of side effects of hormone replacement therapy. |
| Cardiology: | angina pectoris subacute stage of myocardial infarction (to improve the rheological properties of blood). |
| Pulmonology: | sinusitis, bronchitis, pneumonia. |
| Gastroenterology: | pancreatitis, hepatitis. |
| Nephrology: | pyelonephritis, glomerulonephritis. |
| Endocrinology: | diabetic angiopathy, diabetic retinopathy, autoimmune thyroiditis. |
| Rheumatology: | rheumatoid arthritis, reactive arthritis, ankylosing spondylitis. |
| Dermatology: | atopic dermatitis, acne. |
| Surgery: | prevention and treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery. |
| Traumatology: | injuries, fractures, distortions, injuries of the ligamentous apparatus, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine. |
| Neurology: | multiple sclerosis. |
| Pediatrics: | atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (inflammation of the upper and lower respiratory tract, pneumonia), juvenile rheumatoid arthritis, prevention and treatment of postoperative complications (suppuration and poor wound healing, adhesion formation, local edema). |
| Ophthalmology: | Uveitis, iridocyclitis, hemophthalmia, diabetic retinopathy, ophthalmic surgery. |
Prevention
microcirculation disorders, post-stress disorders, as well as disruption of adaptive mechanisms. Prevention of side effects of hormone replacement therapy, hormonal contraception. During surgical interventions in order to prevent infectious complications and adhesive disease.
Contraindications
Individual intolerance to the drug. Diseases associated with an increased likelihood of bleeding (hemophilia, thrombocytopenia, etc.). Carrying out hemodialysis. Children's age up to 5 years.
Use during pregnancy and lactation
Pregnancy and lactation are not a contraindication for the use of the drug, however, pregnant women should take WOBENZIM under the supervision of a physician.
Method of application and dose
Tablets should be taken orally, at least 30 minutes before meals, without chewing, with water (200 ml.).
adults
Depending on the activity and severity of the disease, WOBENZIM is taken at a dose of 3 to 10 tablets 3 times a day. In the first three days of taking the drug, the recommended dose is 3 tablets 3 times a day.
With an average activity of the disease, WOBENZIM is prescribed at a dose of 5-7 tablets 3 times a day for 2 weeks. In the future, the dose of WOBENZYMA should be reduced to 3-5 tablets 3 times a day, a course of 2 weeks.
With high disease activity, WOBENZIM is prescribed at a dose of 7-10 tablets 3 times a day for 2-3 weeks. In the future, the dose of WOBENZYMA is reduced to 5 tablets 3 times a day, the course is 2-3 months.
In case of chronic long-term diseases, WOBENZYM can be used according to indications in courses from 3 to 6 months or more.
In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, WOBENZYM should be used throughout the course of antibiotic therapy at a dose of 5 tablets 3 times a day. After stopping the course of antibiotics to restore the microflora (biocenosis) of the intestine, WOBENZYM should be prescribed 3 tablets 3 times a day for 2 weeks.
As a "cover-up" therapy during chemotherapy and radiotherapy, WOBENZIM should be used at a dose of 5 tablets 3 times a day until the end of the course of chemotherapy and radiotherapy; to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.
When using WOBENZYMA with a preventive purpose
the dose of the drug is 3 tablets 3 times a day, the course is 1.5 months, repeated 2-3 times a year.
Children
Children from 5 to 12 years old - per 6 kg of the child's weight 1 tablet per day. From 12 years old according to the scheme for adults. The dosage and duration of treatment depend on the severity of the disease and are determined by the doctor.
Side effect
WOBENZIM is well tolerated by patients. In most cases, side effects, withdrawal syndrome, addiction were not observed even with long-term treatment with high doses. In some cases, there are slight changes in the consistency and smell of feces, skin rashes in the form of urticaria, which disappear with a decrease in the dose of the drug or withdrawal.
If other adverse reactions occur that are not noted in the instructions, it is recommended to stop taking the drug and consult a doctor.
Overdose
Cases of drug overdose are unknown.
Interaction with other drugs
When taking WOBENZYMA with other drugs, cases of incompatibility are not described.
special instructions
In the case of infectious processes, WOBENZYM does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and the focus of inflammation.
It should be borne in mind that at the very beginning of taking the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, and a temporary reduction in the dose of the drug is recommended.
The drug is not doping and does not have a negative impact on driving a car and performing work that requires a high rate of mental and physical reactions.
Release form
Tablets are packed in blisters of 20 pcs. and placed in cardboard boxes of 2, 10 blisters with enclosed instructions for use.
Packing - 800 tablets contains tablets in high-density polyethylene bottles with enclosed instructions.
Storage conditions
List B.
In a dry dark place at a temperature of 15 to 25 ° C, out of the reach of children.
Best before date
Term 2.5 years. Do not use after the stated expiration date.
Terms of dispensing from pharmacies
Without recipe.
Manufacturer
MUKOS Pharma GmbH & Co., Germany,
produced by MUKOS Emulsions GmbH, Germany
For additional information, contact the General Representative Office of MUKOS Pharma in Russia:
St. Petersburg, Millionnaya st., 11, Moscow
