Gout is a chronic progressive disease caused by impaired purine metabolism, characterized by an increased (normal for adult women - 150-350 μmol / L; for adult men - 210-420 μmol / L) uric acid content in the blood (hyperuricemia), followed by deposition of urate in articular and / or periarticular tissues. Detecting hyperuricemia is not enough to make a diagnosis, as only 10% of people who suffer from this disease have gout. Almost 95% of people diagnosed with gout are men in the age range from 40 to 50 years, although it is noted that the disease is "getting younger."
The rest are women in menopause. Gout is more and more often accompanied by such separate diseases as obesity, hypertriglyceridemia (an increase in the level of neutral fats in the blood) and insulin resistance (a violation of the amount of insulin in the blood). It can be concluded that gout is not a cause, but a consequence of metabolic disorders in the body. There are two types of gout: primary and secondary. Primary gout is a hereditary disease (11-42% of cases), which is associated primarily with a predisposition to hyperuricemia, which is transmitted in an autosomal dominant manner.
The cause of primary gout is the impaired activity of enzymes that are involved in the formation of uric acid from purine bases or in the mechanisms of excretion of urate by the kidneys. And the causes of secondary gout are renal failure, blood diseases, accompanied by increased catabolism (processes aimed at the destruction of substances in the body), and the use of a number of drugs (diuretics, salicylates, etc.).
Lesions
The main function of the kidneys is filtration and absorption actions, which are aimed at removing harmful and hazardous substances from the body, in particular, waste products. The reserves of uric acid in the body are 900-1600 mg, while about 60% of this amount is replaced daily by new formation due to the breakdown of nucleotides and erythroblasts and the synthesis of nitrogen-containing compounds.
With prolonged hyperuricemia (with increased production of uric acid in the body), adaptive reactions develop to reduce the level of uric acid in the blood. This is due to an increase in the activity of the kidneys and the deposition of urate in the soft tissues of the cartilage. The clinical symptom of gout is associated precisely with the deposition of uric acid crystals in soft tissues. Although the mechanism of urate deposition is not fully understood, there are two main factors:
- Insufficient vascularization (penetration of blood vessels) of tissues, such as tendons and cartilage, in which there is an increased concentration of urate.
- Local temperature, pH of blood serum and the presence of substances that retain urates in the liquid (proteoglycans) all affect the sedimentation rate of uric acid salts. Increasing the diffusion of water from the joint increases the concentration of crystallized urates.
It has been proven that the complete dissolution of uric acid salts occurs at pH = 12.0-13.0 (strongly alkaline solution), which in reality exists inside the human body. Hypothermia of the peripheral joints (ankles, phalanges of the fingers) promotes accelerated crystallization of urates and the formation of microtofuses. With a high concentration of microcrystals in tissues (cartilage of joints, epiphyses of bones, etc.), the formation of micro- and macrotofuses begins. Sizes range from grain millet to chicken eggs. The accumulation of urates leads to the destruction of cartilage. Further, uric acid salts begin to be deposited in the subchondral bone (the foundation for cartilage, providing its trophism) with its destruction (the X-ray name is a symptom of a punch).
Uric acid also accumulates in the kidneys (gouty kidney or gouty nephropathy). In all patients with gout, the kidneys are affected, so renal failure is considered not as a complication, but as one of the visceral (internal) manifestations of the disease. Gouty kidney (nephropathy) can manifest as urolithiasis, interstitial nephritis, glomerulonephritis, or arteriolonephrosclerosis.
Gout symptoms
- a symptom of severe pain in one or more joints - the intensity of pain increases over several hours;
- a symptom of swelling or burning, as well as redness of the skin in sore joints and limbs;
- sometimes a symptom of a slight fever;
- a symptom of recurring pain that occurs with a prolonged course of gouty arthritis;
- a symptom of the formation of hard white lumps under the skin (tophus);
- a symptom of renal failure, stones.
Gouty arthritis and its classification
In total, 4 different clinical stages are distinguished:
- acute gouty arthritis;
- interictal (interval) gout;
- chronic gouty arthritis (exacerbation, remission);
- chronic tofus arthritis.
Gout and its clinic
There are three stages in the development of gout. The premorbid period is characterized by asymptomatic formation of an increased amount of uric acid in the body and / or discharge of urate stones with or without colic attacks. This period can be quite long. The onset of attacks of the first gouty crisis indicates that the disease began to develop actively.
Gouty arthritis
In the intermittent period, acute attacks of gouty arthritis alternate with asymptomatic intervals between them. Long-term hyperuricemia and exposure to provocative factors (alcohol consumption, prolonged fasting, eating food rich in purines, trauma, drug use, etc.) in 50-60% lead to nighttime acute attacks of gouty arthritis. The onset of an attack is a sharp pain in the first metatarsophalangeal joint of the leg (big toe). The site of the lesion quickly swells, the skin becomes hot from a sharp rush of blood, the swelling tightens the skin, which acts on pain receptors. Shiny, tense, red skin soon becomes bluish-purple, accompanied by peeling, fever, leukocytosis. There is a violation of the function of the joint, the attack is accompanied by a fever. Other spherical joints, joints of the foot are also affected, somewhat less often - ankle and knee joints.
Less common affected elbow, wrist and hand joints; extremely rare - shoulder, sternoclavicular, hip, temporomandibular, sacroiliac and spinal joints. Known acute gouty bursitis (inflammation of the mucous bags, mainly of the joints), usually affects the prepatellar (located under the skin in front of the kneecap) or elbow bursa. Under the influence of synovitis (inflammation of the synovial membranes of the joint), the joints are deformed, the skin in the focus of inflammation becomes tense, shiny, taut, and when pressed, the fossa disappears. The boundaries of hyperemia (circulatory disorders) are indistinct, bordered by a narrow strip of pale skin. This picture is observed from 1-2 to 7 days, then the local inflammatory processes decrease, but the pain can sometimes continue at night. Gouty arthritis begins to subside after a few days with proper treatment. Initially, the redness of the skin disappears, its temperature normalizes, and later the pain and swelling of the tissues disappear. The skin wrinkles, its profuse pityriasis peeling, local itching is noted. Occasionally, gout-specific tophuses appear. The early stages of intermittent gout are characterized by rare recurrence of attacks (1-2 times a year). But the longer the disease progresses, the more often the symptoms of gouty arthritis return, becoming more prolonged and less severe.
Each time, the intervals between attacks of the disease are reduced and cease to be asymptomatic, and in blood tests, an increased content of uric acid can be detected. This is an indicator that the disease is becoming chronic. Chronic gout is described by the onset of tophi and / or chronic gouty arthritis. The disease develops 5-10 years after the first attack and is characterized by chronic inflammation of the joints and periarticular (periarticular) tissues, the appearance of tofuses (subcutaneous deposits of uric acid crystals), as well as combined damage to the joints (polyarthritis), soft tissues and internal organs (usually the kidneys) ...
The location of the tofuses is different: it can be the auricles, the area of the elbow joints, hands, feet, Achilles tendons. The presence of tofuses indicates a progressive inability of the body to remove uric acid salts at a rate equal to the rate of their formation.
Chronic tofus gout
When gouty arthritis develops for quite a long time, the formation of tofuses occurs everywhere: in cartilage, in internal organs and bone tissues. Subcutaneous or intradermal formations consisting of monocrystals of sodium urate in the area of the fingers and toes, knee joints, elbows and ears are a sign that gouty arthritis has become chronic. Sometimes ulcers can be noted on the surface of the tofuses, from which spontaneous discharge of a white pasty mass is possible. The formation of tophi in the bone space is called a punch or fracture symptom, which can be diagnosed with an X-ray.
Nephrolithiasis (kidney stones) with gout occurs due to the deposition of urate in the kidneys, forming stones. The more actively hyperuricemia progresses and the rate of crystal deposition increases, the more likely it is that tofus formations will appear in the early stages of the disease. This is often observed against the background of chronic renal failure in elderly women taking diuretics; with some forms of juvenile gout, myeloproliferative diseases (associated with a malfunction of brain stem cells) and post-transplant (cyclosporin) gout. Usually, the presence of tophi of any localization is combined with chronic gouty arthritis, in which there is no asymptomatic period, and is accompanied by polyarthritis (multiple joint damage).
General diagnostics
Gout is a disease that is difficult to diagnose in the early stages, since most of the time it is asymptomatic, and during periods of acute attacks it resembles reactive arthritis in its course. Therefore, an important part of the diagnosis of gout is the analysis of the content of uric acid in the blood, in daily urine and the clearance (clearance rate) of uric acid.
During the period of an attack, laboratory acute-phase reactions are detected, in the analysis of urine, slight proteinuria, leukocyturia, microhematuria are possible. Deterioration of the concentration capacity of the kidneys according to the Zimnitsky test indicates the presence of asymptomatic interstitial nephritis (inflammation of the kidneys) with the gradual development of nephrosclerosis (proliferation of connective tissue in the kidneys). In the synovial fluid, there is a decrease in viscosity, high cytosis, the needle-like structure of sodium urate crystals is visible under a microscope. Morphological examination of subcutaneous tophus reveals a whitish mass of sodium urate crystals against the background of dystrophic (degrading) and necrotic tissue changes, around which an inflammatory reaction zone is visible. The mild course of the disease is characterized by rare (1-2 times a year) attacks of gouty arthritis, which occur in no more than 2 joints. On radiographs there are no signs of articular destruction, single tophuses are observed.
A moderate course of gout is characterized by a more frequent (3-5 times a year) exacerbation of the disease, which progresses at once in 2-4 joints, there is moderate skin-articular destruction, multiple tophuses, and kidney stone disease is diagnosed. In a severe course of the disease, seizures are observed with a frequency of more than 5 times a year, multiple joint lesions, pronounced osteoarticular destruction, multiple large tophi, severe nephropathy (kidney destruction).
X-ray diagnostics
In the early stages of gouty arthritis, X-ray examination of the affected joints is of little information. The X-ray phenomenon, typical of late gout, is a rather well-known phenomenon of the "punch-hole". This is a defect of the bone on which the joint rests, it can be 5 mm in diameter or more, it is located in the middle part of the base of the diaphysis (the middle part of the long bones) or in the head of the phalanx, more often the first metatarsophalangeal joint. But with the accumulation of information, it became clear that more often a situation is observed when radiological changes are not detected in patients with gouty arthritis.
Manifestation of the punch symptom
It is necessary to note a number of points that make the radiological symptoms of the punch significant. The pathomorphological (i.e., internal structure differing from the norm) substrate of this X-ray phenomenon is intraosseous tophus, which is similar to cystic (having a separate wall and cavity) formation, due to the fact that uric acid salt crystals do not delay X-rays. The identified "punch" defines the stage of the disease as chronic topiosis. It is worth noting that the identification of tofus of any location is a direct indication for starting anti-gout therapy. In general, the “punch” symptom in patients with primary gout is a late symptom, associated with a long course of the disease and chronic arthritis.
On the other hand, an early X-ray sign in gout is a reversible diffuse thickening of soft tissues during an acute attack due to the fact that during inflammatory processes there is a rush of blood and the deposition of solid crystalline forms in places of edema. In this case, a local rarefaction of bone substance (transient arthritis) can be detected, with the course of the disease, destructive processes in this area can also occur. X-ray manifestations: at first, erosion can form along the edges of the bone in the form of a shell or shell with overhanging bony edges, with clearly defined contours, which is very typical in gouty arthritis, in contrast to rheumatoid arthritis, tuberculosis, sarcoidosis, syphilis, leprosy. Erosive processes can be found both in the joint itself and outside it.
With intra-articular localization of tofuses, destructive processes begin from the edges and, as they develop, move to the center. Extra-articular erosion is usually localized in the cortical layer of the metamiphyses (from the medulla of the edges of the long tubular bone) and the shaft of the bones. Most often, this erosion is associated with the nearby adjacent soft tissue tophus and is defined as rounded or oval marginal bone defects with pronounced sclerotic changes at the base of the erosion. Without treatment, such "holes" increase in size, covering the deeper layers of bone tissue. They look like "rat bites" on the X-ray. Asymmetric erosions with destruction of cartilage are typical; bone ankylosis (fusion of articular surfaces) is rarely formed. If calcium is present in the tofus structures, then X-ray-positive inclusions can come to light, which sometimes stimulate chondromas (a tumor consisting of cartilage tissue). The joint space of the affected joints usually remains normal until the late stages of gouty arthritis. These changes can mimic osteoarthritis (joint degradation), but in some cases both conditions occur.
Stages of joint damage
- tophus in the bone adjacent to the joint capsule and in deeper layers, rarely - manifestations of soft tissue compaction - gouty arthritis is just developing;
- large tophus formations near the joint and small erosions of the articular surfaces, increasing compaction of periarticular soft tissues, sometimes with a certain amount of calcium - gouty arthritis manifests itself in acute attacks;
- severe erosion on at least 1/3 of the joint surface, complete aseptic resorption of all articular tissues of the pineal gland, significant compaction of soft tissues with calcium deposits - chronic gouty arthritis.
Prediction of the consequences of gout
With timely recognition and treatment of gout, you can avoid unpleasant consequences or flow into a chronic form of the disease. Adverse factors that affect the degree of development of the disease: age up to 30 years, persistent hyperuricemia exceeding 0.6 mmol / l (10 mg%), persistent hyperuricosuria exceeding 1100 mg / day, the presence of urolithiasis in combination with urinary tract infection; progressive nephropathy, especially in combination with diabetes mellitus and arterial hypertension. Life expectancy is determined by the development of renal and cardiovascular pathology. In conclusion, it should be noted that gout is a difficult-to-diagnose systemic disease, the symptoms of which are different and often overlap with various other diseases.
Only in 10% of cases, the doctor can immediately diagnose gout, since its early form is sluggish, almost asymptomatic. That is why it is important to monitor diseases that have obvious external manifestations (pain or deformation of any part of the body), and the state of the blood. Blood is an indicator of a person's condition. A timely diagnosed gout will allow you to choose the most effective treatment. And if the final diagnosis was made only at a late stage, then, in order to be able to move normally (gout affects the joints, deforming them), only surgery and a long rehabilitation period will help with no guarantee that the disease will not return again. Be healthy!
Be sure to consult your doctor before treating diseases. This will help to take into account individual tolerance, confirm the diagnosis, make sure that the treatment is correct and exclude negative drug interactions. If you use prescriptions without consulting a doctor, then it is entirely at your own risk. All information on the site is presented for informational purposes only and is not a medical aid. All responsibility for the application lies with you.
Sometimes, by the name of the drug, you can understand its purpose. A striking example is “ wobenzym ", for what this remedy is prescribed, any connoisseur of Latin will say. But for most of the population, additional explanations will be needed, "dead" languages are taught not so often.
Some types of diseases.
It should be understood that the mechanism of the development of the disease may lie both external and internal factor:
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Autoimmune disease. |
Disease caused by exogenous factors. |
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It usually manifests itself against the background of a general weakening of the body. |
There is always an external source, which is the trigger. |
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Most often it occurs against the background of other chronic disorders. |
The primary disease, rarely when it develops against the background of other conditions. |
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It develops as a result of an attack by the immune system of the cells of its own body. |
Throughout the disease, the immune system is trying to cope with the infection that has got inside. |
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It often has a hereditary nature and severe consequences. The prognosis may be unfavorable. |
It can be of both hereditary and acquired nature. The prognosis depends on the stage and severity of the condition. |
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For treatment, drugs are used that suppress the immune system. |
In therapy, agents that increase the level of immune defense are used. |
What is our immunity capable of?
Sometimes our immune system can take up arms against the tissues of our own body, the first signs:
- Recognition on the principle of "friend or foe" is violated.
- The cells in our body are perceived as foreign.
- Specialized lymphocytes are produced that attack the structures of their own body.
- Symptoms of an autoimmune disease appear.
- Without qualified help, the outcome can be tragic.
Pathology is not the most common and active attention was paid to its treatment only in the twentieth century. Before that, patients were doomed to a short and not very comfortable life.
However, even today it cannot be said that absolutely all violations of this kind are treated , but medicine has taken a huge step forward. This is especially noticeable in pharmaceutical industry, which is one wobenzym.
In what situations is wobenzym prescribed?
The tablets should be taken as directed by your doctor if you have such ailments:
- Autoimmune thyroiditis.
- Rheumatoid arthritis.
- Angina pectoris.
- Ischemic heart disease... (Cardiac ischemia)
- Chronic inflammatory process in the lungs.
- Chronic diseases of the gastrointestinal tract and urinary system are also treated with this drug, it quickly relieves inflammation and improves the general condition of the patient.
But the use of wobenzym does not end there, it will find a place even in the HPC due to its ability to relieve swelling... The medicine will not kill the bacteria that caused the venereal disease, but it will make the patient's life much easier.
Use the drug and ophthalmologists, also for inflammatory diseases, but already the eyes.
To simplify a little - Wobenzym can be used wherever inflammation may occur.
But then what's the point in the name, because enzyme translates as enzyme ... But our enzymes have little to do with the elimination of inflammatory processes, they are designed to somewhat speed up the course of chemical reactions in the body. They increase their intensity, facilitate the launch of some processes. They have no special relationship to inflammatory, and even more so autoimmune processes.
Appointment of "Wobenzym" for problems with digestion
The fact is that the preparation also contains enzymes of the human body... Basically, they stimulate the work of the gastrointestinal tract, somewhat simplifying the task of our stomach and intestines.
To start the process of absorption of nutrients, it is necessary to pre-grind them. This is done at the expense of mechanical and chemical processing:
- Mechanics- the movement of the walls of the stomach and intestines, this is called peristalsis and is provided by involuntary movements of the muscles. With age, the number of peristaltic movements decreases significantly, and patients begin to complain of constipation.
- Completeness chemical reactions, as you may already have understood, provide enzymes in our body. Some of them are produced directly in the stomach, but the main percentage is accounted for pancreas .
As a result of taking the drug, not only the load on the enzyme system of the body decreases, but also the process of assimilation of food increases. Basic physics and chemistry - small particles are absorbed and broken down much faster and with greater efficiency.
Why shouldn't you self-medicate?
Wobenzym also affects the blood system.... Stimulates blood flow in small vessels by reducing the level of blood clots. Roughly speaking, blood thinns ... This is another plus in terms of taking the drug. in old age.
But this effect also adds a whole list of contraindications, because any impact on the blood system can lead to serious consequences.
In no case should this type of medication be taken before surgery. If the OR team is not notified in advance, there will be little chance of coping with persistent bleeding.
Doctors like to prescribe wobnzim due to the fact that it is combined with many drugs, enhancing their effect. This must be taken into account when choosing a dose of the same antibiotics, so as not to cause too much damage to the body. The patient prefers this drug:
- For the speed of action. After a couple of days, the patient will feel a sharp improvement.
- Restoration of lipid and protein metabolism.
- Decrease in the level of manifestation of symptoms.
- Removal of pain symptoms.
But, despite all the listed advantages, caution and discretion when prescribing this medication, it will not be superfluous.
Having found a new entry and a few unfamiliar words in their medical record, everyone immediately turns to the Internet for an explanation. But what is wobenzym, what is it prescribed for and what contraindications it has - all this must be explained by the attending physician.
Video about the purpose and use of "Wobenzym"
300 units chymotrypsin (moreover pancreatin is presented in units (U) of the European Pharmacopoeia, and the rest of the ingredients in units (U) of the International Pharmaceutical Federation).
Additional components: stearic acid, lactose, talc, corn starch, purified water, magnesium stearate, colloidal silicon dioxide.
Shell composition: povidone, shellac, sucrose, copolymer of methyl methacrylate and methacrylic acid, vanillin, talc, white clay, titanium dioxide, macrogol 6000, carnauba wax, triethyl citrate, bleached wax, dyes (crimson 4R and yellow-orange S).
Release form
Wobenzym is produced in the form of tablets in a shell of 40 or 200 pieces in packs and 800 pieces in high density polyethylene bottles.
pharmachologic effect
Immunomodulatory, fibrinolytic, antiplatelet, anti-inflammatory, decongestant.
Pharmacodynamics and pharmacokinetics
According to the Medical Wikipedia (MedViki), Wobenzym is a complex of highly active animals and vegetable (inzymes ). Data enzymes carefully selected, optimally combined and included in Wobenzym tablets, from which they have a fairly wide range of clinical applications.
Taking Wobenzym has a positive effect on the course inflammatory process , reduces pathological symptoms immunocomplex and reactions , has a positive effect on immunological reactivity the human body. Under the action of active ingredients of drugs, the number of circulating drugs decreases immune complexes and the removal of their membrane deposits from tissues is carried out. The drug activates and corrects functionality natural killers ( ) and monocyte-macrophages , stimulates cellular activity, cytotoxic T lymphocytes and antineoplastic , for which the medicine Wobenzym is often prescribed as .
Treatment with Wobenzym reduces the infiltration of interstitial tissue plasma cells , increases the elimination of deposits fibrin and protein detritus from the inflamed area, forcing the lysis of metabolic and dying tissue structures, reduces swelling , accelerates resorption and also normalizes the permeability of the vascular walls.
The use of the drug leads to a decrease in the content thromboxane , decrease platelet aggregation , stabilization of adhesion of blood cells, increasing plasticity and their ability to change their own shape, normalizing the number and reducing the total number of their activated fractions, regulating blood viscosity and a decrease in the total amount microaggregants ... Thanks to these effects, rheological parameters of blood and her microcirculation , which determines the normal supply of tissues and organs of the human body with nutrients and oxygen.
Wobenzym lowers replication endogenous , normalizes metabolism lipids , increases concentration HDL , reduces the content of atherogenic lipoproteins and improves absorption polyunsaturated fatty acids .
The appointment of Wobenzym enhances the effectiveness of the antibiotic therapy by increasing the level funds in the focus of inflammation and their plasma concentrations, starts the process of nonspecific defense of the body (production ), thereby exhibiting antimicrobial and antiviral effects, and also neutralizes symptoms. Also, the drug reduces the severity of side effects that occur when taking hormonal medicines (including hypercoagulability ).
When taken orally, due to resorption dimeric molecules , the active ingredients of Wobenzym are absorbed from the small intestine with the formation of protein complexes and further entry into the vascular bed. Circulating through the systemic circulation, enzymes fall into the zones of pathological processes, where they accumulate.
Indications for the use of Wobenzym
Annotation to Wobenzym positions it as a means for use in combination with other drugs used to treat certain pathologies, as an adjunct to the main treatment. Indications for the use of the drug cover many areas of medicine and recommend its appointment in the following cases.
In angiology:
- lymphatic;
- endarteritis ;
- post-thrombophlebitic disease;
- arterial obliterans of the legs ;
- recurrent phlebitis (prevention).
In gynecology:
- miscarriage (relative to the II and III trimester);
- salpingo-oophoritis;
- vulvovaginitis ;
- decrease in the severity and frequency of negative phenomena during hormone replacement therapy;
In gastroenterology:
- (dysbiosis);
- chronic inflammatory pathologies of the gastrointestinal tract;
In dermatology:
- (acne );
- itchy dermatoses.
In neurology:
- circulatory disorders of the brain of a chronic nature;
In cardiology:
- in the subacute stage;
- stresses .
In nephrology:
In otorhinolaryngology:
In ophthalmology:
- uveitis;
- hemophthalmus;
- ophthalmic surgery and prevention of postoperative complications.
In oncology:
- and (to improve portability);
- reducing the risk of secondary infections.
In pulmonology:
- pneumonia;
In dentistry:
- diseases of the oral cavity of an infectious and inflammatory nature.
In rheumatology:
- of various etiologies.
In urology:
- cystopyelitis.
In traumatology:
- inflammatory processes of soft tissues;
- various ;
- post-traumatic manifestations chronic nature;
- sports injuries.
In pediatrics:
- pathology of the respiratory tract of infectious and inflammatory origin;
- postoperative complications ( , insufficient wound healing, local edema and suppuration ).
In surgery:
- lymphatic and post-traumatic edema ;
- postoperative complications ( , , inflammation ).
In endocrinology:
- and angiopathy (diabetic);
- autoimmune .
Additionally, indications for Wobenzym include the prevention of the following conditions:
- and adaptation;
- microcirculation disorders ;
- post-stress disorders;
- vascular accidents ;
- negative phenomena during ;
- viral infections or their subsequent complications;
- violations dysbiotic character at antibiotic therapy .
Contraindications
Before taking Wobenzym, you should familiarize yourself with the contraindications to its appointment, for which the following are conditions in which treatment with Wobenzym is absolutely prohibited:
- any pathologies occurring with an increased risk of possibility ;
- age up to 5 years;
- personal hypersensitivity to active and / or additional components of drugs;
- holding .
Side effects
Therapy with Wobenzym in most cases is tolerated without negative effects in the course of treatment and negative consequences after its completion. Also, until now, there has been no evidence of side effects of the drug, addictive to him or forming withdrawal syndrome , even in the case of prolonged therapy using high dosages.
In isolated cases, the occurrence of , as well as minor deviations in smell and stool consistency , which are leveled by a decrease in the dose of drugs or disappear after discontinuation of treatment.
Before prescribing Wobenzym, you need to warn the patient that in case of any adverse reactions associated with taking the drug, his duties include immediate discontinuation of therapy and further consultation with a doctor.
Wobenzym tablets, instructions for use
As a rule, the dosage regimen, like the duration of treatment, is determined on an individual basis, taking into account the disease itself, its severity, as well as all internal and external factors affecting the patient's condition.
For adult patients, the range of single doses of the drug, depending on the pathology, its severity and activity, is 3-10 tablets with the obligatory three times a day. Usually, during the first three days of therapy, they resort to taking 3 tablets three times every 24 hours. The further number of pills taken at one time may vary, while the frequency of their intake per day in all cases remains unchanged (3 times in 24 hours).
At moderate painful conditions appoint 5-7 tablets three times a day for 14 days. In the future, they switch to taking 3-5 tablets with the same frequency of administration. The general course of treatment is approximately 30 days.
At severe painful conditions appoint 7-10 tablets three times a day for 14-21 days. Subsequently, the dosage is reduced to 5 tablets with the same frequency of administration. The general course of therapy is 2-3 months.
At chronic pathologies Wobenzym tablets are recommended to be taken according to indications and observed symptoms, in courses from 3 to 6 months.
To potentiate the effectiveness of the antibiotic therapy and preventing the formation dysbiosis recommend three times daily intake of 5 tablets throughout the course of use. In order to treat dysbiosis that has arisen after antibiotic therapy, appoint 3 tablets three times in 24 hours for 14 days.
Taking into account some similarity in the composition of drugs and the spread of their effects on the human body, two analogous drugs can be distinguished - Vobe-mugos E and .
The price of Wobenzym analogues (40 tablets) (using the example of these two drugs closest in action) is slightly higher in Phlogenzyme - 950 rubles and much higher for Vobe-mugos E - 2900 rubles, for the same number of tablets.
For children
Wobenzym can be prescribed to children who have reached the age of 5 years. At the age of 5-12 years, the dosage of the drug is calculated per kilogram of weight (1 tablet per 6 kilograms).
With alcohol
It should be noted right away that with any pathology, taking any medications, and even against the background of complete health, alcohol, especially in large quantities, cannot benefit the human body. Considering the compatibility of treatment with Wobenzym with the intake of alcoholic beverages, one should also take into account the fact that this drug itself is prescribed quite rarely, but mainly it is part of the complex treatment of certain diseases, which indicates a variety of possible effects of complex therapy on the body as a whole. and on its individual organs and systems. For example, when combined with antibiotics , antiviral drugs , chemotherapy drinking alcohol is strictly prohibited, and with other combinations of drugs, its intake is undesirable and, at best, can lead to decrease in efficiency therapy, and at worst cause various severe complications ... Another area of application of the drug is treatment withdrawal symptoms and in this case, Wobenzym and alcohol are compatible as well as the very concepts of benefit and harm.
Wobenzym during pregnancy and lactation
The list of contraindications to the use of Wobenzym is absent as , so and. Moreover, during pregnancy, women are even advised to take it for prevention of miscarriage, starting from the second trimester, where the action of the drug receives positive reviews. During pregnancy, the calculation of the dosage and the duration of taking the pills is determined on an individual basis, taking into account the general condition of the expectant mother, fetal health indicators and the course of the pregnancy itself.
Reviews about Wobenzym
Reviews about Wobenzym on the forums, however, like the reviews of doctors about Wobenzym, are quite contradictory and often lead to serious disputes among specialists and patients about the effectiveness, usefulness and safety of using this drug. The opinions of many doctors and people who have ever taken this drug on this score differ radically, and when some argue that for them the complex treatment with the inclusion of Wobenzym was much more effective and safer than without it, others immediately find many arguments against and state about the complete uselessness of this drug.
For example, some nutritionists advise taking Wobenzym for weight loss in combination with and physical education and explain this by the ability of the drug to normalization of the function of the digestive tract and them microflora ... Some of the patients who have undergone such a course of diet therapy remain satisfied with its results and leave positive reviews about Wobenzym. The other part, who does not notice any special changes in body weight, naturally ascribes a negative result to Wobenzym.
Reviews of the drug in gynecology with ; at mastopathy , endometritis , vulvovaginitis , preeclampsia , cervicia ; diseases of sexual etiology ( chlamydia , mycoplasmosis , ureaplasmosis ), as well as reviews of Wobenzym at pregnancy mostly positive, but even here there are those who see in this only a confluence of circumstances and the effect of other drugs taken in parallel.
In this situation, it is not possible to draw any definite conclusions, and therefore we can only advise you to rely on the opinion of your attending physician, especially if you trust him not only as a good specialist, but also as just a decent person.
Wobenzym price where to buy
The price of Wobenzym in Russian pharmacies, due to its considerable cost, does not differ much depending on the region, and therefore you can buy Wobenzym in Moscow for about the same as it costs in St. Petersburg, for example, in the Ozerki pharmacy.
The average price of 40 tablets is 450 rubles; 200 tablets - 1900 rubles; 800 tablets - 6,500 rubles. The price of 100 Wobenzym tablets, when purchased "by weight" from a package of 800 pieces, is 900-1000 rubles.
Wobenzym can be bought in Kiev on average for: №40 - 200 hryvnia; No. 200 - 900 hryvnia; No. 800 - 3000 hryvnia.
- Online pharmacies in Russia Russia
- Online pharmacies of Ukraine Ukraine
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Wobenzym tab. b.p. n200Mukos Emulsions GmbH
Wobenzym tab. n40Mukos Emulsions GmbH
Wobenzym tab. p / o ksh / sol. No. 100Mukos Emulsions GmbH
Wobenzym tab. bp n800Mukos Emulsions GmbH
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Wobenzym (tab.p / v. No. 40)
Wobenzym (tab. P / o No. 800)
Wobenzym (tab. P / o No. 200)
Eurofarm * 4% discount with a promo code medside11
Wobenzym n800 tablMukos Emulsions GmbH
Wobenzym n200 tabMukos Emulsions GmbH
Wobenzym No. 40 tablMukos Emulsions GmbH
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PaniApteka
Wobenzym tablets Wobenzym coated tablets No. 40
Wobenzym tablets Wobenzym coated tablets No. 800Germany, Mucos Emulsionsgesellschaft
Wobenzym tablets Wobenzym coated tablets No. 200Germany, Mucos Emulsionsgesellschaft
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Education: Graduated from Vinnitsa National Medical University named after V.I. NI Pirogov, Faculty of Pharmacy, higher pharmaceutical education - specialty "Pharmacist".
Work experience: Work in the pharmacy chains "Konex" and "Bios-Media", specializing in "Pharmacist". Work in the specialty "Pharmacist" in the pharmacy chain "Avicenna" in the city of Vinnitsa.
Note!
Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before using the drug Wobenzym, be sure to consult with your doctor.Reviews
I do not tolerate antibiotics very well, usually stomatitis on the mucous membranes is added. That is, you are sick and you can't even take anything into your mouth, it's all sores and it hurts. The doctor prescribed Wobenzym for better antibiotic absorption. Indeed, there was no stomatitis, she tolerated the medication well and recovered pretty quickly. Now I will know if I have to take antibiotics again.
My husband suffered for a long time with chronic prostatitis, different doctors gave different treatments. But only with the introduction of wobenzym into the treatment was it possible to cure this chronicity. The course is expensive and long, but the health of a man and well-being in the family is worth the money.
For a long time she was treated for endometriosis, doctors prescribed one treatment, then another. The effect appeared when a course of wobenzym was prescribed. The doctor said that he kind of stimulates the treatment, helps and accelerates it. The drug is natural, so there was no addiction, although it had to be taken for a long time.
Before (and after) a small gynecological operation, she started taking Wobenzym to prevent the appearance of adhesions. And after that I also drank, as it helps the body recover faster. The gynecologist was pleased with his result.
Wobenzym was prescribed to me after a gynecological operation, so that the tissues were restored better, and adhesions did not form, there the enzymatic composition was very well selected. The drug helped - everything healed quickly, and without consequences
Took it 2 times, very happy. For the first time they were discharged after the operation so that adhesions would not form, the second - he cured thrush, the doctor recommended wobenzym to enhance the action of antifungal drugs and raise immunity so that it does not recur.
2 years could not conceive a baby. We were already thinking about going to IVF. And then I went to another gynecologist and it turned out that I just had adhesions in the tubes after the inflammation. The doctor immediately prescribed wobenzym for resorption of pathological tissues and prescribed a course of electrophoresis with enzymes. And already 3 months after the treatment, I became pregnant!
Wobenzym was taken two months after giving birth to accelerate the recovery process of the body. I really recovered quickly, after a month at the examination they said that all the seams from the ruptures were almost completely healed. Maybe, of course, this is just my natural feature that tissues are so quickly restored and wounds are healed (although I did not notice this before), but the fact that wobenzym strengthened my immunity, I can say for sure. I gave birth in October, now it is June, and during all this time I have never caught a cold, even a slight runny nose, can you imagine ?! Although before the snot flowed immediately, as soon as the breeze blows. So as an immunostimulant, it definitely works.
This drug was prescribed by a gynecologist after laparoscopy. She explained to me that wobenzym in inflammatory processes is a good remedy and will raise immunity at the same time. I drank it for one month. To my happiness, no new adhesions were formed. And the blood test showed good results - the inflammation passed quickly.
Wobenzym is a universal drug. I drink it when I am sick with viral diseases - to raise immunity. I also parted with the thrush thanks to him. For several years now, there has been no thrush, and before that she constantly crawled out and gave me a lot of discomfort and discomfort. I think women who have come across this will understand me. In general, I advise all the fair sex.
Wobenzym is a find drug for me. Its enzymes improve the functioning of the whole body. I periodically drink a course of wobenzym and feel great. The first time he was prescribed to me by a gynecologist for inflammation of the appendages. When I began to drink it, the pain in the lower abdomen immediately disappeared, apparently it also has an analgesic effect.
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Trade name of the drug: WOBENZYM ®
Dosage form: enteric-coated tablets (dragees).
Composition:
Active substances:
Pancreatin 345 prot. Eur.Pharm.- U, papain 90 FIP-U, rutoside 3 H 2 O 50.00 mg, bromelain 225 FIP-U, trypsin 360 FIP-U .. lipase 34 FIP-U .. amylase 50 FIP- U, chymotrypsin 300 FIP-U
Excipients:
Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc.
Sucrose, talc, methacrylic acid-methyl methacrylate copolymer, shellac, titanium dioxide, white clay, yellow-orange dye S (E110), crimson dye 4R (E124), povidone, macrogol 6000, triethyl citrate, vanillin, bleached wax, carnauba wax.
Description: Round biconvex tablets with a smooth surface, with a characteristic odor, colored red-orange. Variations in the color intensity of the outer shell from red-orange to red are allowed.
Pharmacotherapeutic group: anti-inflammatory, immunomodulatory agent.
ATX code E03AX
Pharmacological properties
WOBENZYME is a combination of natural plant and animal enzymes. Entering the body, enzymes are absorbed in the small intestine by resorption of intact molecules and, by binding to transport proteins in the blood, enter the bloodstream. Subsequently, the enzymes, migrating along the vascular bed and accumulating in the zone of the pathological process, have an immunomodulatory, anti-inflammatory, fibrinolytic, decongestant, antiplatelet and secondary analgesic effect.
VOBENZIM has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, and has a positive effect on the indicators of the body's immunological reactivity. It stimulates and regulates the level of functional activity of monocytes-macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.
Under the influence of WOBENZIME, the number of circulating immune complexes decreases and membrane deposits of immune complexes are removed from tissues.
VOBENZIM reduces the infiltration of the interstitium by plasma cells. Increases the elimination of protein detritus and fibrin deposits in the area of inflammation, accelerates the lysis of toxic metabolic products and necrotic tissues. Improves resorption of hematomas and edema, normalizes the permeability of the walls of blood vessels.
VOBENZIME reduces the concentration of thromboxane and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of erythrocytes to change their shape, regulating their plasticity, normalizes the number of normal discocytes and reduces the total number of activated forms of platelets, normalizes blood viscosity, reduces the total number of microaggregates, thus improving microcirculation and rheological properties of blood, as well as tissue supply oxygen and nutrients.
VOBENZIM reduces the severity of side effects associated with the intake of hormonal drugs (hypercoagulation, etc.).
VOBENZIM normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the content of high density lipoproteins, lowers the level of atherogenic lipids, and improves the absorption of polyunsaturated fatty acids.
VOBENZIM increases the concentration of antibiotics in the blood plasma and the site of inflammation, thus increasing the effectiveness of their use. At the same time, enzymes reduce the unwanted side effects of antibiotic therapy (dysbiosis) by improving the environment.
VOBENZIM regulates the mechanisms of nonspecific defense (production of interferons), thereby exhibiting antiviral and antimicrobial effects.
Indications for use
Applicable in complex therapy the following diseases:
| Angiology: | thrombophlebitis, treatment of post-thrombophlebitic disease and acute thrombophlebitis of superficial veins, endarteritis and obliterating atherosclerosis of the arteries of the lower extremities, prevention of recurrent phlebitis, lymphatic edema. |
| Urology: | cystitis, cystopyelitis, prostatitis, sexually transmitted infections. |
| Gynecology: | chronic infections of the genitals, adnexitis, gestosis, mastopathy, to reduce the frequency and severity of side effects of hormone replacement therapy. |
| Cardiology: | angina pectoris subacute stage of myocardial infarction (to improve the rheological properties of blood). |
| Pulmonology: | sinusitis, bronchitis, pneumonia. |
| Gastroenterology: | pancreatitis, hepatitis. |
| Nephrology: | pyelonephritis, glomerulonephritis. |
| Endocrinology: | diabetic angiopathy, diabetic retinopathy, autoimmune thyroiditis. |
| Rheumatology: | rheumatoid arthritis, reactive arthritis, ankylosing spondylitis. |
| Dermatology: | atopic dermatitis, acne. |
| Surgery: | prevention and treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery. |
| Traumatology: | injuries, fractures, distortions, injuries of the ligamentous apparatus, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine. |
| Neurology: | multiple sclerosis. |
| Pediatrics: | atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (inflammation of the upper and lower respiratory tract, pneumonia), juvenile rheumatoid arthritis, prevention and treatment of postoperative complications (suppuration and poor wound healing, adhesion formation, local edema). |
| Ophthalmology: | Uveitis, iridocyclitis, hemophthalmus, diabetic retinopathy, ophthalmosurgery. |
Prophylaxis
microcirculation disorders, post-stress disorders, as well as disruption of adaptive mechanisms. Prevention of side effects of hormone replacement therapy, hormonal contraception. With surgical interventions for the prevention of infectious complications and adhesive disease.
Contraindications
Individual intolerance to the drug. Diseases associated with an increased likelihood of bleeding (hemophilia, thrombocytopenia, etc.). Carrying out hemodialysis. Children under 5 years of age.
Application during pregnancy and lactation
Pregnancy and lactation are not a contraindication for the use of the drug, however, pregnant women should take VOBENZIM under the supervision of a physician.
Method of administration and dose
The tablets should be taken orally, at least 30 minutes before meals, without chewing, with water (200 ml).
Adults
Depending on the activity and severity of the disease, WOBENZIM is taken in a dose of 3 to 10 tablets 3 times a day. In the first three days of taking the drug, the recommended dose is 3 tablets 3 times a day.
With an average activity of the disease, VOBENZIM is prescribed in a dose of 5-7 tablets 3 times a day for 2 weeks. In the future, the dose of WOBENZIME should be reduced to 3-5 tablets 3 times a day, the course is 2 weeks.
With a high activity of the disease, VOBENZIM is prescribed in a dose of 7-10 tablets 3 times a day for 2-3 weeks. In the future, the dose of WOBENZIME is reduced to 5 tablets 3 times a day, the course is 2-3 months.
In case of chronic long-term current diseases, VOBENZIM can be used according to indications in courses of 3 to 6 months or more.
In order to increase the effectiveness of antibiotics and prevent dysbiosis, VOBENZIM should be used throughout the course of antibiotic therapy in a dose of 5 tablets 3 times a day. After stopping the course of antibiotics to restore the microflora (biocenosis) of the intestine, VOBENZIM should be prescribed 3 tablets 3 times a day for 2 weeks.
As a "cover-up" therapy during chemotherapy and radiation therapy, VOBENZIM should be used in a dose of 5 tablets 3 times a day until the end of the course of chemotherapy and radiation therapy; to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.
When using WOBENZIME for prophylactic purposes
the dose of the drug is 3 tablets 3 times a day, the course is 1.5 months, repeated 2-3 times a year.
Children
Children from 5 to 12 years old - 1 tablet per day for 6 kg of the child's weight. From 12 years old according to the scheme for adults. The dosage and duration of treatment depends on the severity of the disease and is determined by the doctor.
Side effect
VOBENZIM is well tolerated by patients. In most cases, side effects, withdrawal symptoms, addiction were not observed even with long-term treatment with high doses. In some cases, there are slight changes in the consistency and odor of feces, skin rashes in the form of urticaria, which disappear with a decrease in the dose of the drug or withdrawal.
If other adverse reactions occur that are not noted in the instructions, it is recommended to stop taking the drug and consult a doctor.
Overdose
Cases of drug overdose are unknown.
Interaction with other medicinal products
No cases of incompatibility have been described while taking WOBENZIME with other medications.
special instructions
In the case of infectious processes, VOBENZIM does not replace antibiotics, but increases their effectiveness, increasing the concentration in the blood plasma and the focus of inflammation.
It should be borne in mind that at the very beginning of taking the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, but a temporary reduction in the dose of the drug is recommended.
The drug is not doping and does not have a negative effect on driving a car and performing work that requires a high speed of mental and physical reactions.
Release form
Tablets are packed in blisters of 20 pcs. and placed in cardboard boxes of 2, 10 blisters with enclosed instructions for use.
Packaging - 800 tablets contains tablets in high density polyethylene bottles with enclosed instructions.
Storage conditions
List B.
In a dry, dark place at a temperature of 15 to 25 ° C, out of the reach of children.
Shelf life
The term is 2.5 years. Do not use after the stated expiration date.
Terms of dispensing from pharmacies
Over the counter.
Manufacturer
MUKOS Pharma GmbH & Co, Germany,
produced by MUKOS Emulsions GmbH, Germany
For more information, contact the General Representative Office of MUKOS Pharma in Russia:
Saint-Petersburg, Millionnaya street, 11, Moscow
Wobenzym is a highly effective drug. It is a complex of highly active animals and plant enzymes (inzymes).
It combines enzymes of animal and plant origin with the addition of rutoside. It has immunomodulatory and anti-inflammatory effects, affects reparative processes. They are widely used in various branches of medicine and are used to improve the body's health as part of the complex treatment of various kinds of diseases.
On this page you will find all the information about Wobenzym: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Wobenzym. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
A drug with anti-inflammatory and immunomodulatory effects.
Terms of dispensing from pharmacies
Dispensed without a doctor's prescription.
Prices
How much does Wobenzym cost? The average price in pharmacies is 480 rubles.
Release form and composition
Round biconvex tablets with a smooth surface, no cracks, with a characteristic light vanilla odor, colored orange-red. Variations in the color intensity of the outer shell from orange-red to red are allowed.
- Active substances: Pancreatin 345 prot. - Europe. Farm. - U, papain - 90 FIP-U, rutoside ZH2O 50.00 mg, bromelain 225 FIP-U, trypsin 360 FIP-U, lipase 34 FIP-U, amylase 50 FIP-U, chymotrypsin 300 FIP -Ed.
Excipients: Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc. Sucrose, talc, calcium carbonate, copolymer of methacrylic acid - methyl methacrylate, shellac, titanium dioxide, white clay, yellow-orange dye S (E 13 0), crimson dye 4 R (E 124), povidone, macrogol 6000, triethyl citrate, vanillin, bleached wax, carnauba wax.
Pharmacological effect
Wobenzym is a combination of highly active enzymes of plant and animal origin with immunomodulatory, anti-inflammatory, decongestant, fibrinolytic and secondary analgesic effects.
Enzymes (enzymes) are the basis of the body's life and take part in almost all biological processes of the body. Reduced enzyme activity often leads to acute and chronic diseases. Wobenzym has a positive effect on the course of the inflammatory process, limits the pathological manifestation of autoimmune and immunocomplex processes, and has a positive effect on the indicators of the body's immunological reactivity. It stimulates and regulates the level of functional activity of monocytes-macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.
Under the influence of Wobenzym, the number of circulating immune complexes decreases and membrane deposits of immune complexes are removed from tissues. Wobenzym accelerates the lysis of toxic metabolic products and necrotic tissues. Improves resorption of hematomas and edema, normalizes the permeability of the walls of blood vessels. Normalizes blood viscosity and microcirculation. Improves the supply of oxygen and nutrients to tissues. Wobenzym reduces thromboxane concentration and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of erythrocytes to change their shape, regulating their plasticity, normalizes the number of normal discocytes and reduces the total number of activated forms of platelets, normalizes blood viscosity, reduces the total number of microaggregates, thus improving microcirculation and rheological properties of blood, as well as tissue supply oxygen and nutrients. Wobenzym reduces the side effects associated with taking hormonal drugs.
The secondary analgesic effect of Wobenzym is manifested through the effect on the causative factors of the acute inflammatory process. Wobenzym normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the content of high density lipoproteins, lowers the level of atherogenic lipids, improves the absorption of polyunsaturated fatty acids. Wobenzym increases the concentration of antibiotics in the blood plasma and the site of inflammation, thus increasing the effectiveness of their use. At the same time, enzymes reduce the unwanted side effects of antibiotic therapy. Wobenzym regulates the mechanisms of nonspecific defense (production of interferons), thereby exhibiting antiviral and antimicrobial effects.
Indications for use
As part of the complex treatment, the indications for the use of Wobenzym are:
- , ankylosing spondylitis;
- Multiple sclerosis;
- Acne, ;
- Iridocyclitis, uveitis, hemophthalmus;
- , and cystopyelitis;
- Glomerulonephritis;
- Diabetic retinopathy and angiopathy;
- , postphlebitic syndrome, atherosclerosis of the arteries of the lower extremities and obliterating endarteritis, lymphatic edema;
- Sexually transmitted infections;
- Chronic infections of the genitals, mastopathy, gestosis;
- stress and subacute stage;
- Bruises, injuries, fractures, damage to the ligamentous apparatus, chronic post-traumatic processes, burns, inflammation of soft tissues;
- Postoperative complications, reconstructive and plastic surgery.
It is also recommended to prescribe in order to prevent post-stress disorders, disruption of adaptive mechanisms, microcirculation disorders, side effects of hormonal contraception, adhesive disease and infectious complications during surgery, as well as during radiation or chemotherapy.
Contraindications
Wobenzym is usually well tolerated, but there are several contraindications:
- blood diseases with a risk of bleeding;
- renal failure, hemodialysis procedures;
- age up to 5 years;
- hypersensitivity to the composition of the drug.
Application during pregnancy and lactation
Perhaps the appointment of the drug during pregnancy and lactation. Reception is carried out under strict medical supervision.
Instructions for use
The instructions for use indicate that the dosage of Wobenzym is set individually, depending on the severity of the disease. The drug should be taken at least 30 minutes before meals, without chewing, with water (200 ml).
Adults, depending on the activity and severity of the disease, are prescribed in a dose of 3 to 10 tab. 3 times / day In the first 3 days of taking the drug, the recommended dose is 3 tab. 3 times / day
- With an average activity of the disease, the drug is prescribed in a dose of 5-7 tab. 3 times / day for 2 weeks. In the future, the dose of the drug should be reduced to 3-5 tab. 3 times / day The course is 2 weeks.
- With a high activity of the disease, the drug is prescribed in a dose of 7-10 tab. 3 times / day for 2-3 weeks. In the future, the dose should be reduced to 5 tab. 3 times / day The course is 2-3 months.
- For chronic long-term diseases, Wobenzym can be used according to indications in courses of 3 to 6 months or more.
In order to increase the effectiveness of antibiotics and prevent dysbiosis, Wobenzym should be used throughout the entire course of antibiotic therapy in a dose of 5 tab. 3 times / day After the termination of the course of antibiotic therapy to restore the intestinal microflora, Wobenzym should be prescribed 3 tab. 3 times / day for 2 weeks.
During radiation and chemotherapy, Wobenzym should be used in a dose of 5 tab. 3 times / day until completion of the course of radiation and chemotherapy in order to prevent infectious complications, improve the tolerance of basic therapy and improve the quality of life.
For prophylactic purposes, Wobenzym is prescribed 3 tab. 3 times / day for 1.5 months with a repetition of the course 2-3 times a year.
Children aged 5-12 years are prescribed in a daily dose at the rate of 1 tab. per 6 kg of body weight. For children over 12 years old, the drug is prescribed according to the scheme intended for adults. The duration of treatment is determined individually.
Side effects
The drug is well tolerated, only in some cases it is noted: disorders of the digestive system, nausea, allergic reactions. After feeling discomfort after taking the drug, it is recommended to consult a doctor. Before taking the drug, you need to consult your doctor. Do not self-medicate, which can harm your health or provoke complications.
Overdose
In medicine, there are no cases of overdose with Wobenzym tablets even with prolonged use, however, in order to prevent the development of side effects, the dosage indicated by the doctor should not be exceeded.
special instructions
- At the very beginning of taking the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, but a temporary reduction in the dose of the drug is recommended.
- In the case of infectious processes, Wobenzym does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and the focus of inflammation.
- The drug is not doping and does not adversely affect the ability to drive vehicles and perform work that requires a high speed of mental and physical reactions.
Drug interactions
Wobenzym tablets can be taken simultaneously with other drugs, since the enzymes included in the composition enhance the therapeutic effect of drugs and at the same time reduce the risk of side effects.
It is important to understand that this drug does not replace antibiotics or other drugs for diseases, but only enhances their therapeutic effect.
