What happens if you eat a lot. Ascorbic acid overdose symptoms. So, the harm of ascorbic acid

General characteristics. Composition:

Active substance: ascorbic acid.1 tablet contains ascorbic acid - 0.05 g;Excipients: granulated sugar, starch syrup, food aromatic essence, beeswax, vaseline oil, talc.

Pharmacological properties:

Water-soluble vitamin, eliminates the deficiency of ascorbic acid in the body.
It activates the activity of the endocrine glands, regulates all types of metabolism, blood clotting, tissue regeneration, the formation of steroid hormones, the synthesis of collagen, procollagen, maintains normal capillary permeability. Regulates the content of cholesterol in the blood, promotes the accumulation of glycogen in the liver.
Due to the activation of respiratory enzymes in the liver, its detoxification and protein-forming functions are enhanced, the synthesis of prothrombin is increased.
Promotes the absorption of iron in the intestine and takes part in the synthesis of hemoglobin.
Ascorbic acid, showing a stimulating effect on the body as a whole, increases its adaptive capacity, resistance to infections.

Indications for use:

Diseases in which additional administration of vitamin C is required: for prevention and treatment, with bleeding (uterine, pulmonary, nasal, hemorrhagic diathesis, bleeding arising from), with various intoxications and infectious diseases, pregnant women, Addison's disease, overdose of anticoagulants, bone fractures and long-term non-healing wounds, compliance with reduction diets, during convalescence, pregnancy and lactation, with increased mental and physical stress, as well as for non-specific prevention of infectious diseases.

Important! Check out the treatment

Method of administration and dosage:

Ascorbic acid is administered orally after a meal. Therapeutic dose for adults - 0.05 - 0.1 g (1-2 pills) 3 - 5 times a day. Doses for children depend on the age and nature of the disease: for children from 4 to 18 years old - 0.1 - 0.5 g (2-10 tablets) in 2 - 3 doses per day. The duration is determined by the nature of the pathological process and the effectiveness of therapy (mono- or complex).
For prophylactic purposes, ascorbic acid is prescribed for adults in a daily dose of 0.1 g (2 tablets). Pregnant women and women after childbirth with a low level of vitamin C in breast milk are prescribed the drug in a daily dose of 0.3 g (6 tablets) for 10-15 days, after which (prophylactically throughout the entire period of breastfeeding) - at a dose of 0.1 g (2 tablets).
For prophylactic purposes, children are prescribed a drug from 4 years of age, 0.05 g (1 tablet) per day.

Application features:

Consult your doctor before starting treatment!
The drug should be taken with caution in patients with hypercoagulability.
When the daily dose of ascorbic acid should not exceed 1 g. When using ascorbic acid in high doses, it is necessary to control the function of the kidneys and the level of blood pressure, as well as the function of the pancreas. Lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, but its use in high doses during pregnancy can also adversely affect the development of the fetus. Ascorbic acid passes into breast milk, so vitamin C should be taken under medical supervision during breastfeeding.
Ascorbic acid as a reducing agent can change the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, lactate dehydrogenase).
This dosage form is not recommended for use in children under 4 years of age.

Side effects:

Ascorbic acid is generally well tolerated. With prolonged use in large doses, a negative effect on the digestive tract (nausea, diarrhea), arterial hypertension, metabolic disorders, inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria) and glycogen synthesis, decreased capillary permeability and deterioration of tissue trophism, thrombus formation , myocardial dystrophy, allergic reactions; with prolonged use - the formation of urinary, cystine and oxalate stones. In patients with a lack of glucose-6-phosphate dehydrogenase of blood cells, it can cause hemolysis of erythrocytes.
If you experience any unusual reactions, consult your doctor regarding further use of the drug.

Interaction with other medicinal products:

If you are taking any other medicines, be sure to consult your doctor about the possibility of using the drug!
The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, the use of fresh fruits or vegetable juices, alkaline drinks. Oral ascorbic acid increases the absorption of penicillin, iron, reduces the effectiveness of heparin and indirect anticoagulants, increases the risk of crystalluria during treatment with salicylates.
Reduces the anticoagulant effect of coumarin derivatives. Improves intestinal absorption of iron preparations. Increases the total clearance of ethyl alcohol. Quinoline drugs, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid.
The simultaneous intake of Ascorbic acid and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. It can only be taken 2 hours after deferoxamine injection. Long-term use of large doses in persons treated with disulfiram inhibits the disulfiram-alcohol reaction. Large doses of the drug reduce the effectiveness of tricyclic antidepressants.

Contraindications:

Hypersensitivity to ascorbic acid and other components of the drug; thrombosis, thrombophlebitis, patients with diabetes mellitus.

Overdose:

Symptoms:, vomit, . Therapy is symptomatic.
With prolonged use in high doses, it is possible to suppress the function of the insular apparatus of the pancreas, impaired renal function, and increased blood pressure.

Storage conditions:

Store in a dry, dark place at a temperature of 15° С to 25 ° С ... Keep out of the reach of children.Do not use the drug after the expiration date printed on the package.

Expiration date - 1 year 6 months.

Vacation conditions:

Over the counter

Package:

50 pills each in molten glass jars or polymer containers.

active substance: ascorbic asid;

1 tablet contains 50 mg of ascorbic acid;

auxiliary substances: sugar, starch syrup, talc, yellow wax, food aromatic essence, sunflower oil, tropeolin O.

Medical form

Dragee yellow, regular spherical shape with a smooth, smooth surface.

Manufacturer's name and location

Odessa industrial chemical-pharmaceutical enterprise "Biostimulator" in the form of a limited liability company.

Ukraine, 65006, Odessa, Hadzhibayska road, 2.

Pharmacotherapeutic group

Vitamins. Simple preparations of ascorbic acid. ATC code A11G A01.

Ascorbic acid (vitamin C) has pronounced renewal properties. They belong to the group of water-soluble vitamins. Participates in redox reactions, regulation of carbohydrate metabolism, influences the exchange of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, which is necessary for blood coagulation, collagen and procollagen synthesis, regeneration of connective and bone tissue. Improves capillary permeability. Promotes the absorption of iron in the intestine and is involved in the synthesis of hemoglobin.

Increases nonspecific resistance of the organism, has antidote properties. Deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.

Absorption of ascorbic acid occurs mainly in the small intestine. The absorption process can be disrupted with intestinal dyskinesia, enteritis, achilia, helminthic invasion, giardiasis, as well as when drinking alkaline drinks, fresh fruit and vegetable juices. The maximum concentration of the drug in plasma after ingestion is achieved internally after 4 hours.

Easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the back of the pituitary gland, adrenal cortex, ocular epithelium, intermediate cells of the seminal glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. Metabolized mainly in the liver into deoxyascorbic acid and further into oxalic acid and diketogulonic acid. Ascorbate is unchanged and metabolites are excreted in urine, feces and excreted in breast milk.

When high doses are used, when the plasma concentration reaches more than 1.4 mg / dL, excretion is sharply increased, and the increased excretion can persist after discontinuation of use.

Indication for use

Prevention and treatment of vitamin C deficiency in the body.

Prevention and treatment of scurvy, stimulation of tissue regeneration, in the complex therapy of bleeding (uterine, pulmonary, nasal), with radiation sickness syndrome, bone fractures, hemorrhagic diseases, intoxications and infections, Addison's disease, with an overdose of anticoagulants, during pregnancy and breastfeeding, with increased mental stress and physical overload.

Contraindication

Hypersensitivity to ascorbic acid or to any of the excipients of the drug. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease. Urolithiasis - when using doses over 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome. Children under 3 years old.

Special warnings

When taking high doses and long-term use of the drug, it is necessary to monitor renal function and blood pressure, as well as the function of the pancreas. The preparation should be used with caution in patients with a history of kidney disease.

In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

Do not prescribe large doses of the drug to patients with increased blood clotting.

Since ascorbic acid increases the absorption of iron, its application in high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with a high iron content in the body should use the drug in minimal doses.

The simultaneous administration of the drug with an alkaline drink reduces the absorption of ascorbic acid, therefore, you should not drink pills with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia.

It is used with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency.

Ascorbic acid as a reducing agent can affect the results of laboratory tests, for example, when determining the content of glucose in the blood, bilirubin, transaminase activity, lactate dehydrogenase, and the like.

Since Ascorbic Acid has a mild stimulating effect, it is not recommended to take the drug at the end of the day.

Use during pregnancy or breastfeeding

The lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in high doses can also negatively affect the development of the fetus, therefore, before pregnancy, Ascorbic acid is used exclusively as directed and under the supervision of a physician, strictly adhering to the recommended doses (see section " Method of administration and dosage ").

Ascorbic acid penetrates into breast milk, therefore, during breastfeeding, vitamin C is taken only under the supervision of a physician, adhering to the recommended doses ((see section "Dosage and Administration").

The ability to influence the reaction rate when driving or operating other mechanisms

Does not affect.

Children

The drug is prescribed for children aged 3 years and older.

Method of administration and dosage

It is prescribed for adults and children over the age of 3 years. Dragee is taken internally after meals.

The therapeutic dose for adults and children over the age of 14 is 50-100 mg (1-2 pills) 3-5 times a day, for children aged 3-7 years - 50-100 mg (1-2 pills), age 7- 10 years - 100 mg (2 tablets), aged 11-14 years - 100-150 mg (2-3 tablets) 2-3 times a day.

For prophylactic purposes, Ascorbic acid is prescribed for adults and children over the age of 14 years in a daily dose of 50-100 mg (1-2 pills).

Children aged 4-14 years, in order to prevent hypovitaminosis, are prescribed 50 mg (1 tablet) 1 time per day.

Pregnant women, women after childbirth, as well as with a low content of vitamin C in breast milk are prescribed in a daily dose of 300 mg (6 tablets) for 10-15 days, after which (for prophylactic purposes during the entire period of breastfeeding) - in a daily dose 100 mg (1 tablet).

The duration of use is determined by the doctor depending on the nature of the pathological condition and the effectiveness of therapy.

Overdose

Symptoms: with a single use of excessive doses of the drug, nausea, vomiting, bloating and abdominal pain, itching, skin rashes, increased excitability are possible. With prolonged use in high doses, possible oppression of the insular apparatus of the pancreas (it is necessary to control its function), the development of cystitis, the acceleration of the formation of calculi (urates, oxalates).

Treatment: discontinuation of the drug, symptomatic therapy (gastric lavage, alkaline drink, intake of activated charcoal or other absorbents).

Side effects

Ascorbic acid is generally tolerated

good, however, such side reactions may occur:

on the part of the digestive tract: when used in a dose over 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea;

from the side of the secular system: damage to the glomerular apparatus of the kidneys, crystalluria, the formation of urate, cystine and / or oxalate calculi in the kidneys and urinary tract;

allergic reactions: skin rashes, Kvinke's edema, urticaria; sometimes - anaphylactic shock in the presence of sensitization;

on the part of the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and disorders of glycogen synthesis until the onset of diabetes mellitus;

on the part of the cardiovascular system: arterial hypertension, myocardial dystrophy;

from the hematopoietic system: thrombocytosis, hyperprothrombinemia, erythrocytopenia, neutrophilic leukocytosis; in patients with glucose-6-phosphate dehydrogenase deficiency of blood cells, hemolysis of erythrocytes may result;

from the nervous system: hyperexcitability, sleep disturbance, headache;

from the side of metabolism: metabolic disorders of zinc, copper.

Interaction with other medicinal products and other types of interactions

The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks. When administered orally, ascorbic acid increases the absorption of penicillin, tetracycline, iron, reduces the effectiveness of heparin and indirect anticoagulants, increases the risk of crystalluria during treatment with salicylates.

The simultaneous intake of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can be taken only 2 hours after deferoxamine injection.

Long-term use of high doses in persons treated with disulfiram inhibits the disulfiram-alcohol reaction. Large doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - derivatives of phenothiazine, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys.

Ascorbic acid increases the total clearance of ethyl alcohol. Preparations of the chinoline series, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body.

Expiration date

in 1.5 years.

Storage conditions

Keep out of the reach of children, dry, protected from light at a temperature not exceeding 25 ◦С.

Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food.

Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, except for the rapid elimination of the symptoms of hypo- and avitaminosis (scurvy).

Physiological functions: is a cofactor of some hydroxylation and amidation reactions - transfers electrons to enzymes, supplying them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of kartite synthesis), oxidation of folic acid to folinic acid, drug metabolism and hydroxylation in liver microsomes dopamine with the formation of norepinephrine.

Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands;

Restores Fe3 + to Fe2 + in the intestine, promoting its absorption. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

In low doses (150-250 mg / day orally), it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to an increase in the excretion of the latter.

Ascorbic acid is actively involved in many redox reactions, has a nonspecific general stimulating effect on the body. Increases the adaptive capacity of the body and its resistance to infections; promotes regeneration processes.

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Ascorbic acid dragee instruction

Ascorbic acid dosage

Ascorbic acid is prescribed in the following doses:

Preventive

1. children - 25 mg per day;
2. adults - 50-100 mg per day;

Therapeutic

1. children - 50-100 mg per day;
2. adults - 150-200 mg per day;
3. pregnant and lactating mothers - 250-300 mg per day.

Ascorbic acid dragee composition

1 tablet contains 50 mg of ascorbic acid in terms of pure substance.

Additional components: sugar, molasses, talc, yellow wax, orange flavor, mineral oil, E 104 dye.

Release form

It is produced in the form of a spherical dragee, yellow in color, with a uniformly colored surface.

Vitamin C preparations

Ascorbic acid dragee - pharmacological action

Ascorbic acid is a powerful antioxidant. Protects cell walls from the damaging effects of free radicals by controlling redox reactions. Ascorbic acid affects the following body systems:

Immune.

• stimulation of immunity;
• increasing the body's resistance to infectious diseases;
• reducing the manifestations of inflammation and allergies;
• participation in the restoration of antioxidants - vitamins A and E.

Endocrine.

• stimulation of hormone synthesis;
• increased excretory activity of the pancreas;
• stimulation of the hormonal activity of the thyroid gland.

Digestive.

• stimulation of the synthesis of building proteins in the liver;
• participation in the formation of digestive enzymes;
• increased anti-toxic activity of the liver;
• stimulation of bile secretion.

Cardiovascular and circulatory systems.

• increasing the bioavailability of iron, which is necessary for the formation of hemoglobin;
• lowering the level of "bad" cholesterol in the blood;
• increased blood clotting;
• normalization of the permeability of small vessels.

Indications for use

Ascorbic acid in dragees is indicated for use in such cases:

Indications

• hypo- and vitamin C deficiency;
• period of intensive growth;
• monotonous and unbalanced diet;
• hard mental and physical labor;
• the recovery period after illnesses and operations;
• alcoholic, nicotine and drug addiction;
• stress and depression;
• pregnancy and breastfeeding;
• poisoning with iron preparations;
• anemia;
• hemorrhagic diathesis;
• blood clotting disorders;
• infectious diseases;
• systemic intoxication;
• poorly healing wounds and fractures.

Contraindications

Taking ascorbic acid in pills is contraindicated in the following cases:

• thrombophlebitis;
• predisposition to blood clots;
• diabetes;
• hypersensitivity to the components of the drug;
• acute renal failure;
• exacerbation of urolithiasis;
• intolerance to fructose.

Side effects

In rare cases, taking ascorbic acid in pills can cause allergic reactions. On the part of certain systems of the body, the following symptoms can be observed:

• headache;
• weakness and oppression;
• insomnia;
• excessive excitability.

Digestive.

• nausea and vomiting;
• diarrhea;
• inflammation of the mucous membrane of the stomach and intestines;
• painful abdominal cramps.

Endocrine.

• decreased endocrine function of the pancreas;
• increased blood sugar levels.

Cardiovascular and circulatory system.

• blood clots;
• increased blood pressure;
• myocardial dystrophy.

Laboratory indicators may change - the content of platelets, prothrombin, sodium and neutrophilic leukocytes in the blood will increase, and the number of erythrocytes and potassium will decrease.

How to take ascorbic acid in pills - special instructions

Ascorbic acid stimulates the adrenal cortex, so blood pressure and kidney health should be monitored while taking.

With a long course, you need to monitor the endocrine function of the pancreas. With a high iron content in the blood, ascorbic acid is prescribed in minimal dosages.

In patients with rapidly growing tumors, the drug can accelerate the pathological process. Taking ascorbic acid distorts the results of laboratory tests.

Ascorbic acid - instructions for interaction with other drugs

With the simultaneous use of ascorbic acid in pills with other drugs, the following may be observed:

1. an increase in the blood concentration of antibiotics of the penicillin and tetracycline group;
2. decrease in the effectiveness of drugs that reduce blood clotting;
3. decrease in the bioavailability of ascorbic acid when taking oral contraceptives and alkaline solutions;
4. sulfonamides and salicylic acid increase the risk of crystals in the urine;
5. glucocorticosteroids and calcium preparations reduce the content of ascorbic acid in the body;
6. the effectiveness of antidepressants decreases.

Ascorbic acid dragee instructions for use

Ascorbic acid is taken orally after meals in doses prescribed by the doctor. For children, pills can be dissolved in water and given as a drink.

Overdose

With an overdose of ascorbic acid, the following is observed:

1. abdominal pain;
2. nausea;
3. vomit;
4. diarrhea;
5. bloating;
6. rash;
7. overexcitability of the nervous system;

Taking in large doses over a long period of time can cause a decrease in insulin production and the formation of bladder stones. In case of an overdose, it is necessary to rinse the stomach, take sorbents and immediately consult a doctor.

Terms of sale

Sold in pharmacies without a prescription.

Storage conditions

Store in its original packaging, in a dark place out of the reach of children, at a temperature not exceeding 25 ° C.

Shelf life

Stored for 18 months.

Reviews

The overwhelming majority of consumer reviews confirm the appearance of the indicated pharmacological action after a course of treatment with ascorbic acid in pills. The incidence of side effects coincides with the data stated in the instructions.

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Ascorbic acid: instructions for the use of vitamin C in pills, indications, dosage

What is the composition of ascorbic acid and in what form it is produced. In what cases it is prescribed and how to choose the dosage.

Ascorbic acid (vitamin C) is a substance that the body needs to form collagen, strengthen the structure of bone tissue, capillaries and teeth. The element is involved in the metabolism of tyrosine, redox reactions, the breakdown of carbohydrates, the production of proteins and lipids.

Also, ascorbic acid is an irreplaceable element of cellular respiration. It reduces the need for tocopherol, retinol, vitamins B1 and B2, pantothenic and folic acid. Vitamin C works to strengthen the immune system, absorb iron and perform antioxidant functions. Below are the subtleties of taking and dosing ascorbic acid, instructions for using the drug in the form of pills (50 mg).

Composition and forms

Today, ascorbic acid is available in the form of:

• Tablets - 25 and 50 mg (glucose is added to some drugs).
• Dragee - 50 mg.
• Oral solution - 2.5 g.
• Solution for injection (intramuscular and intravenous).

The most popular form of vitamin C is dragee, which contains:

• Ascorbic acid - 0.05 grams;
• Additional elements are wheat flour, starch syrup, sugar and sunflower oil. Beeswax, fragrances, talc and dyes are also added.

The composition of the auxiliary elements may vary - here a lot depends on the manufacturer of the drug.

Pharmacokinetics

Ascorbic acid (vitamin C) is a substance that has a multifaceted effect on the human body:

• Improving blood clotting.
• Restoration of body cells.
• Participation in oxidative as well as reduction reactions.
• Regulation of amino acid and carbohydrate metabolism.
• Help in the biosynthesis of catecholamines and carbohydrate metabolism.
• Biosynthesis of insulin and steroid hormones.
• Production of procollagen and collagen.
• Regeneration of bone and connective tissue.
• Absorption of iron from food.
• Production of hemoglobin and normalization of blood composition.
• Improving capillary permeability, which reduces the risk of developing cardiovascular diseases.
• Increase in nonspecific resistance of the organism.
• Antioxidant properties.

Lack of ascorbic acid leads to the development of vitamin C deficiency due to the inability of the body to synthesize this vitamin on its own.

After consuming vitamin C pills, it passes into the small intestine, where ascorbic acid is absorbed. Deterioration of the process of assimilation of a substance is possible in the following cases:

• intestinal dyskinesia;
• achilia;
• enteritis;
• giardiasis;
• helminthic invasion;
• drinking alkaline drinks;
• intake of fruits and fresh vegetable juices.

The highest concentration of the drug is achieved four hours after ingestion. The peculiarity of the substance is its rapid penetration into platelets, leukocytes, and then into all tissues of the human body. After that, the substance accumulates in the following parts of the body:

• the back of the pituitary gland;
• ocular epithelium;
• liver;
• ovaries;
• intestinal wall;
• adrenal cortex;
• intermediate cells of the seminal glands;
• spleen;
• pancreas and thyroid gland;
• heart and muscles.

The substance is metabolized primarily in the liver, transforming into deoxyascorbic acid, and then into dykeouglonic and oxaloacetic acids. Excess products (metabolites and ascorbate) are excreted in urine and faeces.

Part of the vitamin C passes into the mother's breast milk, which should be taken into account during the nursing period. In the case of taking the supplement at an increased dosage, when the concentration rises to a level of 1.4 mg / deciliter or more, the excretion of the drug also increases. However, accelerated withdrawal often persists after the supplement is completed.

Indications for use

Vitamin C in pills is prescribed in the following cases:

• Treatment or prevention of vitamin C deficiency (hypo- and avitaminosis).
• Excessive stress (mental and physical).
• A condition when the body needs an increased volume of ascorbic acid.
• Diets or poor nutrition.
• Periods of active growth.
• As part of a comprehensive treatment for alcoholism.
• Long-term chronic infections.
• Chronic intoxication with iron-containing drugs. The need for vitamin C often arises in combination therapy with deforoxamine.
• Nicotine addiction.
• Burn diseases.
• Idiopathic methemoglobinemia.
• Pregnancy, postoperative period.
• Excessive stress associated with work or household troubles. Perhaps the appointment of ascorbic acid for disorders of the central nervous system.
• Feverish conditions that manifest themselves against the background of long-term ongoing respiratory diseases, as well as viral infections.

Dosage

Despite the free sale and safety of the drug, it is important to know how to take vitamin C tablets and strictly follow the recommended dosage. Reception is carried out inside, after eating. The dosage is as follows:

1. For prevention:
   • Adults - 50-100 mg per day (1-2 pills).
   • Children over the age of five years - 50 mg per day (1 tablet).
2. For medicinal purposes:
   • Adults - 50-100 mg (one serving) 3-5 times a day.
   • Children aged five years or more - 50-100 mg (1-2 tablets). The frequency of admission is 2-3 times a day.
3. Pregnancy and lactation period. The first 1.5-2 weeks are taken at 300 mg (6 tablets) per day, after which 100 mg (2 tablets) per day.

The maximum need for ascorbic acid in the 2-3 trimester of pregnancy is 50-60 mg. During the feeding period, it is important that 80-100 mg of vitamin C enter the body. This is enough to prevent a lack of vitamin C in a baby during infancy. During lactation, it is important to control the amount of vitamin intake and avoid overdose, despite the lack of evidence of a negative effect on the child.

During pregnancy, ascorbic acid quickly passes through the placental barrier, so that the fetus quickly adapts to higher dosages. After a newborn child may have a withdrawal reaction. To avoid problems, the dosage of vitamin C during pregnancy must be tightly controlled.

Overdose and side effects

In the case of prolonged use of the drug at a dosage exceeding 1 gram per day, the following problems are possible:

• diarrhea;
• heartburn;
• difficulty urinating;
• urine staining red;
• hemolysis.

Overdose treatment is carried out taking into account the current symptoms. First of all, it is recommended to stop taking the drug, as well as limit the use of foods that contain vitamin C.

During the reception, the following side effects are possible:

1. Malfunctions of the central nervous system:
   • feeling tired;
   • headache;
   • sleep disturbance;
   • CNS excitability.
2. Disruption of the urinary system:
   • hyperoxalaturia;
   • the formation of calcium oxalate;
   • the formation of urinary stones.
3. Digestive system problems:
   • vomit;
   • nausea;
   • irritation of the gastrointestinal mucosa;
   • stomach cramps;
   • diarrhea.
4. Allergic manifestations:
   • skin rash;
   • anaphylactic shock.
5. Malfunctions of the endocrine system (associated with a malfunction of the insular apparatus):
   • hyperglycemia;
   • glucosoria.
6. Disruption of the cardiovascular system:
   • myocardial dystrophy;
   • microangiopathy;
   • increased blood pressure;
   • thrombosis.
7. Change in laboratory parameters:
   • erythropenia;
   • hyperprothrombinemia;
   • thrombocytosis;
   • hypokalemia;
   • neutrophilic leukocytosis.
8. Other problems:
   • increased body temperature;
   • sodium retention;
   • violation of the exchange of zinc and copper;
   • hypovitaminosis;
   • fluid retention in cells.

• anemia;
• renal failure;
• hyperoxalaturia;
• thalassemia;
• hemochromatosis;
• leukemia;
• sideroblastic or sickle cell anemia;
• malignant diseases;
• lack of glucose-6-phosphate dehydrogenase.

Interaction with other drugs

During the period of taking ascorbic acid, the nuances of the interaction of the vitamin with other substances (drugs) should be taken into account. The following action is worth highlighting here:

• Improving the absorption of iron in the intestine, as well as accelerating the removal of metal in the case of combination with Deferoxamine.
• Increased risk of crystalluria during treatment with sulfonamides and sallicites. At the same time, the process of excretion of acids through the kidneys slows down, and the rate of excretion of drugs with an alkaline reaction also increases. In addition, the concentration of oral contraceptives in the blood decreases.
• Depletion of vitamin C reserves in the case of taking salicylates, calcium chloride, and the quinoline series.
• Increasing the total ethanol clearance, which reduces the level of ascorbic acid in the blood and living tissues.
• Decrease in absorption and deterioration in digestibility when combining vitamin C with acetylsalicylic acid, alkaline drinks, oral contraceptives.
• An increase in the volume of tetracyclines and benzylpenicillin in the blood. Also, with an increase in dosage above one gram per day, the bioavailability of ethinyl estradiol increases.
• Increased renal excretion of mexiletine (in the case of taking ascorbic acid in high dosages).
• Acceleration of the excretion of vitamin C in the urine in the case of taking Primidone and barbiturates.
• Decrease in the chronotropic action of isoprenaline (with simultaneous administration).
• Deterioration of the therapeutic effect of tricyclic antidepressants, tubular reabsorption of amphetamine, decrease in the effect of antipsychotics.

special instructions

For vitamin C, the instructions for the use of pills stipulate a number of special instructions that should be followed during the course of the course:

• Reception of ascorbic acid is performed with caution in case of impaired renal function, hyperoxaluria, in the presence of indications of the presence of urolithiasis.
• Due to the increased absorption of iron, high doses of vitamin C are dangerous for people with polycythemia, thalassemia, leukemia, and sideroblastic anemia. For people with a high iron content in the body, it is recommended to limit the intake of ascorbic acid.
• In the case of increased intake, the condition may worsen in the presence of sickle cell anemia.
• There is a high risk of exacerbation if the patient has disseminated or proliferating tumors, which can only aggravate the process.
• Diabetics are advised to keep their glucose levels under control while taking the drug.
• With the use of vegetable or fruit juices, as well as alkaline drinks, vitamin C is absorbed and absorbed worse.
• Due to the stimulating effect of the substance on the production of corticosteroid hormones, it is recommended to monitor kidney function and measure blood pressure periodically.
• During the period of taking ascorbic acid, the readings of many laboratory tests may be distorted.

Analogs

The pharmaceutical sector offers a wide range of preparations containing vitamin C. All of them differ in the amount of active substance, manufacturer, set of auxiliary elements and pricing policy. The most famous drugs include:

• Tsevikap.
• Celascon.
• Multi-Tabs with Vitamin C.
• Askovit.
• Additive Vitamin C.
• Setebe 500.
• Plivit S.
• Celaxon Effectscens.
• Vitamin C PLUS Kid formula Farmamed and others.

Shelf life and storage conditions

Ascorbic acid in the form of pills has a shelf life of 1.5 years. The drug should be stored in a dark and dry place. Storage temperature - up to +25 degrees Celsius.

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Ascorbic acid dragee: instructions for use

Active ingredient: ascorbic acid;

1 tablet contains ascorbic acid - 50 mg;

auxiliary substances: starch syrup, white sugar, yellow wax, mineral oil, talc, orange flavor (contains propylene glycol).

Description

international non-proprietary name: ascorbic acid;

basic physical and chemical properties: white or white with a yellowish tinge dragee color. They should be spherical in appearance.

pharmachologic effect

Ascorbic acid (vitamin C) has pronounced reducing properties. Belongs to the group of water-soluble vitamins. Participates in redox reactions, regulation of carbohydrate metabolism, affects the exchange of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood coagulation, collagen and procollagen synthesis, regeneration of connective and bone tissue. Improves capillary penetration. Promotes the absorption of iron in the intestine and takes part in the synthesis of hemoglobin. Increases nonspecific resistance of the body, has antidote properties. Deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.

Absorption of ascorbic acid occurs mainly in the small intestine. The absorption process can be disrupted with intestinal dyskinesia, enteritis, achilia, helminthic invasion, giardiasis, as well as when drinking alkaline drinks, fresh fruits and vegetable juices. The maximum concentration of the drug in plasma after oral administration is achieved after 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the back of the pituitary gland, adrenal cortex, ocular epithelium, intermediate cells of the seminal glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. It is metabolized mainly in the liver to deoxyascorbic acid and further to oxaloacetic and diketogulonic acids. Unchanged ascorbate and metabolites are excreted in urine, feces and excreted in breast milk. When high doses are used, when the plasma concentration reaches more than 1.4 mg / dL, excretion is sharply increased, and increased excretion may persist after discontinuation of use.

Indications for use

Prevention and treatment of vitamin C deficiency in the body.

Prevention and treatment of scurvy, stimulation of tissue regeneration, in the complex therapy of bleeding (uterine, pulmonary, nasal), with radiation sickness syndrome, bone fractures, hemorrhagic diathesis, intoxications and infections, Addison's disease with an overdose of anticoagulants, during pregnancy and lactation, with increased mental stress and physical overload.

Contraindications

Hypersensitivity to ascorbic acid or to an excipient of the drug. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease. Urolithiasis - when using doses over 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome.

Children under 4 years of age.

Pregnancy and lactation

The lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in high doses can also negatively affect the development of the fetus, therefore, during pregnancy, ascorbic acid is used exclusively as directed and under the supervision of a physician, strictly adhering to the recommended doses (see section " Method of application and dosage ").

Ascorbic acid penetrates into breast milk, therefore, during breastfeeding, vitamin C should be taken under medical supervision, adhering to the recommended doses (see section "Dosage and Administration").

Method of administration and dosage

It is prescribed for adults and children over 4 years of age. Dragee is taken orally after meals. The therapeutic dose for adults and children over 14 years of age is 50-100 mg (1-2 pills) 3-5 times a day.

children aged 4-7 years - 50-100 mg (1-2 tablets), children aged 7-10 years - 100 mg (2 tablets),

children aged 11-14 years - 100-150 mg (2-3 tablets) 2-3 times a day.

For prophylactic purposes, ascorbic acid is prescribed for adults and children over the age of 14 years in a daily dose of 50-100 mg (1-2 pills).

Children aged 4-14 years, in order to prevent hypovitaminosis, are prescribed 50 mg (1 tablet) 1 time per day.

Pregnant women, women after childbirth, as well as with a low level of vitamin C in breast milk are prescribed in a daily dose of 300 mg (6 tablets) for 10-15 days, after which (for prophylactic purposes throughout the entire period of breastfeeding) - in a daily dose 100 mg (2 tablets).

The duration of use is determined by the doctor depending on the nature of the pathological condition and the effectiveness of therapy.

Side effect

Ascorbic acid is generally well tolerated, but the following side reactions may occur:

on the part of the digestive tract: when used in a dose of more than 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea; from the urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, the formation of urate, cystine and / or oxalate calculi in the kidneys and urinary tract;

allergic reactions: skin rash, Quincke's edema, urticaria; sometimes - anaphylactic shock in the presence of sensitization;

on the part of the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis up to the onset of diabetes mellitus;

on the part of the cardiovascular system: arterial hypertension, myocardial dystrophy; from the side) 1y of the hematopoietic system: thrombocytosis, hyperprothrombinemia, erythrocytopenia, neutrophilic leukemia; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, hemolysis of erythrocytes may result;

from the nervous system: hyperexcitability, sleep disturbance, headache; from the side of metabolism: metabolic disorders of zinc, copper.

In case of any undesirable reactions, consult your doctor regarding the further use of the drug!

Overdose

Symptoms: with a single use of excessive doses of the drug, it is possible

the occurrence of nausea, vomiting, bloating and abdominal pain, itching, skin rash, increased excitability.

With prolonged use in high doses, it is possible to suppress the insular apparatus of the pancreas (it is necessary to control its function), the development of cystitis, and the acceleration of the formation of calculi (urates, oxalates).

Treatment: drug withdrawal, gastric lavage, alkaline drink, intake of activated charcoal or other sorbents, symptomatic therapy.

Interaction with other medicinal products

If you are taking any other medicines, be sure to inform your doctor!

The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks. Oral ascorbic acid increases the absorption of penicillin, tetracycline, iron, reduces the effectiveness of heparin and indirect anticoagulants, increases the risk of crystalluria during treatment with salicylates. The simultaneous intake of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can only be taken 2 hours after deferoxamine injection.

Long-term use of large doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction. Large doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys.

Ascorbic acid increases the total clearance of ethyl alcohol. Quinoline drugs, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body.

Application features

The ability to influence the reaction rate when driving or operating other mechanisms. Does not affect.

Children. The drug is prescribed for children over 4 years old.

Precautionary measures

Consult your doctor before starting treatment!

When using the drug, you must adhere to the doses recommended by your doctor!

When taking high doses and long-term use of the drug, it is necessary to monitor renal function and blood pressure, as well as the function of the pancreas. Should be used with caution in patients with a history of kidney disease.

In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

Do not prescribe large doses of the drug to patients with increased blood clotting.

Since ascorbic acid increases iron absorption, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with a high iron content in the body should use the drug in minimal doses.

Simultaneous reception with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink pills with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia. It is used with caution to treat patients with glucose-6- deficiency.

phosphate dehydrogenase.

Ascorbic acid as a reducing agent can affect the results of laboratory studies, for example, when determining the blood glucose, bilirubin, transaminase activity, lactate dehydrogenase, etc.

Since Ascorbic Acid has a mild stimulating effect, it is not recommended to take the drug at the end of the day.

Release form

50 tablets with a dosage of 50 mg in containers. 1 container in a carton box.

Storage conditions

Store in original packaging at temperatures above 25 ° C.

Shelf life

1 year 6 months

Conditions of dispensing from pharmacies

Without a doctor's prescription.

Ascorbic acid pills analogs, synonyms and group drugs

Self-medication can be harmful to your health. You should consult your doctor and read the instructions before use.

Ascorbic acid belongs to the group of vitamins.

Available in the following forms: pills, lyophilisate for the subsequent preparation of a solution for intravenous and intramuscular injections, drops for oral administration, solution for intravenous use, powder for preparation of a solution for oral administration.

Pharmacological action of Ascorbic acid

Ascorbic acid is not formed in the human body, therefore, it is necessary to ensure the intake of the substance inside with food. Vitamin takes part in the regulation of redox processes, blood clotting, carbohydrate metabolism, tissue regeneration. Also, Ascorbic acid makes the body more resistant to various infections, reduces vascular permeability, reduces the need for vitamins A, E, B1 and B2, pantothenic and folic acids. Vitamin is involved in the metabolism of tyrosine, phenylalanine, folic acid, Fe, histamine, norepinephrine. It also promotes the utilization of carbohydrates, the synthesis of lipids, carnitine and proteins, and the hydroxylation of serotonin.

Ascorbic acid has antioxidant and antiplatelet properties, regulates the movement of H + in various biochemical reactions, takes part in the formation of tetrahydrofolic acid and tissue renewal, improves the use of glucose in the tricarboxylic acid cycle, promotes the synthesis of collagen, steroid hormones and procollagen.

The pharmacological properties of the vitamin include maintaining the colloidal state of the intercellular substance, normal capillary permeability; activation of proteolytic enzymes; participation in the exchange of pigments, cholesterol and aromatic amino acids; promoting the accumulation of glycogen in the liver. Ascorbic acid enhances protein-forming and detoxification functions of the liver by activating respiratory enzymes. It also improves bile secretion, promotes the rapid restoration of the exocrine function of the pancreas and endocrine function of the thyroid gland.

According to the instructions, Ascorbic acid activates the synthesis of antibodies, interferon and complement component C3. It also promotes phagocytosis, slows down the release and accelerates the degradation of histamine. In small doses, the vitamin improves the complexing function of deferoxamine in cases of chronic poisoning with Fe preparations, which leads to an increase in the excretion of the latter. The required dosage for this is 150-250 mg of the drug per day.

Indications for the use of Ascorbic acid

From the instructions for Ascorbic acid it is known that the indications for taking vitamins are:

• Hypo- and vitamin C deficiency;
• Unbalanced diet;
• Increased need for ascorbic acid (for example, during periods of intensive growth or artificial feeding);
• Hard work;
• Parenteral nutrition;
• Convalescence period after serious illness;
• Alcoholism;
• Scurvy;
• Prolonged hypothermia of the body;
• Burn disease;
• Chronic infections
• Prolonged fever;
• Diseases of the gastrointestinal tract such as peptic ulcer, persistent diarrhea, gastrectomy, resection of the small intestine;
• Hyperthyroidism;
• Frequent stress;
• Smoking;
• Trauma;
• Postoperative rehabilitation;
• Pregnancy (especially multiple pregnancy, as well as against the background of drug or nicotine addiction);
• Breast-feeding;
• Idiopathic methemoglobinemia;
• Chronic poisoning with Fe preparations.

Contraindications to the use of Ascorbic acid

According to the instructions, Ascorbic acid is contraindicated in case of hypersensitivity to this vitamin, as well as its individual intolerance.

The drug is prescribed with caution to people suffering from diabetes mellitus, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, thalassemia, oxalosis, kidney stones, hemochromatosis and hyperoxaluria.

Side effects

From the side of the central nervous system, side effects such as fatigue and dizziness may occur (with rapid intravenous administration of the drug).

In the digestive system, irritation of the mucous surfaces of organs may appear if the patient takes Ascorbic acid orally.

Allergic reactions are not excluded: redness of the skin and rash. Laboratory findings may indicate erythropenia, hyperprothrombinemia, thrombocytosis, hypokalemia, and neutrophilic leukocytosis.

If a person often and intensively takes the drug orally, then the likelihood of tooth enamel destruction increases.

In case of an overdose (more than 1 g), the following symptoms are likely to occur:

• Increased CNS excitability;
• Headache;
• Diarrhea;
• Nausea and vomiting;
• Hyperacid gastritis;
• Insomnia;
• Ulceration of the mucous membrane of the digestive tract;
• Hyperglycemia and glucosuria;
• Nephrolithiasis;
• Hyperoxaluria
• Moderate pollakiuria (at a dosage of more than 600 mg per day);
• Decrease in capillary permeability, which is accompanied by an increase in blood pressure, deterioration of tissue trophism, the development of microangiopathies and hypercoagulation;
• Termination of pregnancy and hemolysis of erythrocytes (with the introduction of the drug intravenously in high doses).

Dosing and Administration of Ascorbic Acid

According to the instructions, Ascorbic acid is taken orally after meals (in accordance with the dosage form of the drug).

For prophylactic purposes of vitamin C deficiency, dosages are shown:

• adults - 50-100 mg per day;
• children - 25-75 mg per day.

In the treatment of Ascorbic acid, it is indicated in the following doses:

• adults - from 50 to 100 mg at a time 3-5 times a day for 2 weeks;
• children - 50-100 mg twice or three times a day for 2 weeks.

In powder form, the vitamin preparation is diluted with water and taken as a drink. The proportion should be 1 g per liter of water or juice. With intramuscular and intravenous administration, the drug is prescribed in a volume of 50-150 mg, in case of poisoning - 60 mg. The maximum allowable dose is 200 mg at a time, the daily dose is 1 g. Children should not exceed the dosage of the drug - 100 mg per day.

Ascorbic acid with glucose

One tablet of ascorbic acid with glucose contains the main component ascorbic acid - 0.1 g and dextrose (glucose) - 0.877 g. The drug is used to fill the lack of vitamin C.

Also, Ascorbic acid with glucose is used for pulmonary, nasal, uterine, hepatic and other bleeding, hemorrhagic diathesis, liver diseases, intoxication of the body, infectious diseases, Addison's disease, poorly healing wounds, bone fractures, dystrophy, intense physical and mental stress, pregnancy and breastfeeding. The drug is prescribed for adrenal insufficiency and during the period of accelerated growth, like the usual version of the vitamin.

Contraindications and dosages of Ascorbic acid with glucose are identical to the classic drug.

Ascorbic acid is the name of the popular vitamin C. It participates in many processes in the human body, therefore it is recommended to use it for various diseases and for their prevention. Its main feature is a beneficial effect on immunity, which protects us from all sorts of ailments. Taking vitamin C during a cold or flu has been shown to reduce the risk of complications that often affect the bronchi and lungs. Therefore, it is recommended to consume a sufficient amount of fruits containing it.

But it is not always possible to completely make up for the deficiency in this way. Indeed, this vitamin does not accumulate in the body. And then ascorbic acid comes to the rescue. For medical purposes, it is obtained synthetically. It has a very high concentration of vitamin C, so that you do not have to eat a kilogram of oranges in one sitting, but it will be enough to take a vitamin.

Ascorbic acid - instructions for use

Pharmacological group - vitamin-like agents, vitamins.

Ascorbic acid - composition: vitamin C.

Method of production: dragee, powder.

Dragee composition: 0.05 g Additional substances - sugar, sunflower oil, talc, wax, starch syrup, yellow dye, aromatic essence.

Powder composition: 2.5 g of ascorbic acid. Crystalline white powder with sour taste, odorless. No excipients.

Ascorbic acid - instructions for use: indications

Vitamin C deficiency, hypovitaminosis, vitamin deficiency.

Pulmonary, nasal, uterine, hepatic and other bleeding.

Intoxication, infectious diseases.

Various liver diseases.

Poor ulcers, fractures, burns and other injuries.

Recovery of the body with increased physical and mental stress.

The period of intensive development of the body, breastfeeding and pregnancy.

Without the special prescription of a doctor, the drug is recommended to be taken in case of tooth loss, bleeding gums, hair loss, excessive dry skin, general soreness, irritability, weakness and depression.

Ascorbic acid - application and dosage

It is assigned depending on the specific purpose. The required daily amount of this vitamin is taken as a basis. For adults it is 70-100 mg, for children from six months to a year - 20 mg, from one to one and a half years - 35 mg, from one and a half to two years - 40 mg, from three to four years - 45 mg, from five to ten years old - 50 mg, from eleven to thirteen years old - 60 mg, from 14 to 17 years old - 70-80 mg. Therapeutic doses for children are 50 to 100 mg two or three times a day.

In the treatment of serious diseases, it is administered intravenously under the supervision of a physician.

Ascorbic acid - instructions for use: contraindications

It practically does not have such, since it is pure vitamin C.

It is recommended to be careful in case of individual sensitivity to the components of the drug, thrombophlebitis, diabetes mellitus. And also with renal failure, leukemia, anemia, progressive malignant diseases.

During pregnancy, it is worth consulting with your doctor about the best dosage.

Ascorbic acid - instructions for use: side effects:

Diarrhea, headache, nausea, high CNS excitability, high blood pressure, allergic reactions, fever, hypervitaminosis.

Most of the side effects occur when the drug is taken too high. If you notice these symptoms, see your doctor for advice.

Pregnancy and breastfeeding

The minimum requirement for these periods is 60-80 mg per day. However, the recommended daily dose should not be exceeded, as this may affect the condition of the fetus.