Name:
Valocordin (Valocordin)
Pharmacological
action:
Pharmacodynamics. Valocordin is a combination drug containing phenobarbital and ethyl bromoisovalerianate (ethyl ester of α-bromoisovaleric acid). Depending on the dose, both of these substances have a sedative, hypnotic effect, and in high doses - a narcotic effect. Like other derivatives of barbituric acid, phenobarbital inhibits the inhibitory system of the reticular formation. Ethyl bromisovalerianate has both antispasmodic and sedative effects. At the concentration contained in Valocordin, ethyl bromisovalerianate acts as a synergist of phenobarbital (rapid manifestation of the effect).
Pharmacokinetics. Phenobarbital is absorbed quickly (directly in the stomach). About 35% binds to plasma proteins, the part that is not bound to proteins is filtered in the kidneys.
Reabsorption occurs at low pH levels. Back diffusion does not occur due to the alkalinity of the urine. About 30% of phenobarbital is excreted unchanged in the urine, and only a small part is oxidized in the liver.
With prolonged use, there is an accumulation of the active substance in the blood plasma, as well as the induction of liver enzymes. As a result of this induction, the process of oxidation of phenobarbital and other drugs is accelerated.
Bromine from ethyl bromisovalerianate is excreted very slowly from the body. If the drug is used for a long time, it accumulates in the central nervous system, which leads to chronic bromine intoxication.
Indications for
application:
Functional disorders of the cardiovascular system (including cardialgia, sinus tachycardia);
- neurosis, accompanied by irritability, anxiety, fear;
- insomnia (difficulty falling asleep);
- states of excitation, accompanied by pronounced vegetative reactions.
Mode of application:
Valocordin is taken orally, before meals, with a small amount of liquid. The dosage is set individually.
Adults usually prescribed 15-20 drops 3 times / day. In case of disturbed falling asleep, the dose can be increased to 30 drops.
children prescribed at the rate of 1 drop per year of a child's life and depending on the clinical picture of the disease.
The duration of the drug is set individually by the doctor.
Side effects:
Valocordin is generally well tolerated even with prolonged use.
In some cases, drowsiness and slight dizziness may occur during the daytime.
With prolonged use of large doses, chronic bromine poisoning may develop, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
If you experience any side (unusual) effects that are not reflected in the instructions, you must report them to your doctor.
Contraindications:
Severe impairment of kidney and / or liver function;
- pregnancy,
- lactation period;
- hypersensitivity to any of the components of the drug.
The drug contains 55 vol% ethanol and phenobarbital, therefore Valocordin®, even when used correctly, may impair the ability of patients to respond quickly in certain situations, such as when being outdoors or while servicing cars.
This is especially pronounced with the simultaneous intake of alcohol.
With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning them.
Interaction
other medicinal
by other means:
When using the drug with other drugs that depress the central nervous system, a mutual enhancement of the action (sedative-hypnotic effect) is possible, which may be accompanied by respiratory depression. Alcohol enhances the effect of the drug and may increase its toxicity.
Medicines containing valproic acid increase the effect of barbiturates.
Phenobarbital induces liver enzymes and, accordingly, can accelerate the metabolism of certain drugs that are metabolized by liver enzymes (for example, coumarin derivatives, antibiotics and sulfonamides). Phenobarbital enhances the effect of analgesics, anesthetics, anesthetics, neuroleptics, tranquilizers; reduces the effect of paracetamol, indirect anticoagulants, metronidazole, tricyclic antidepressants, salicylates, digitoxin.
Possible effect on blood concentrations of phenytoin, as well as carbamazepine and clonazepam. MAO inhibitors prolong the effect of phenobarbital. Rifampicin may reduce the effect of phenobarbital. When used with gold preparations, the risk of kidney damage increases. With prolonged simultaneous use with NSAIDs, there is a risk of gastric ulcers and bleeding.
The simultaneous use of drugs containing phenobarbital with zidovudine increases the toxicity of both drugs. Undesirable interaction Valocordin(contains phenobarbital) with lamotrigine, thyroid hormones, doxycycline, chloramphenicol, antifungal drugs (azole group), griseofulvin, corticosteroids, oral contraceptives due to the possible weakening of the action of these drugs.
Increases the toxicity of methotrexate.
Pregnancy:
Contraindicated. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.
Overdose:
Symptoms. Acute (mild to moderate) barbiturate poisoning: dizziness, fatigue, deep sleep from which the patient cannot be awakened.
Hypersensitivity reactions may occur: angioedema, urticaria, itching, rash.
Acute severe poisoning: deep coma accompanied by tissue hypoxia, shallow breathing, first accelerated and then slowed down, increased heart rate, arrhythmia, hypotension, bradycardia, vascular collapse, decrease or loss of reflexes, nystagmus, headache, nausea, weakness, impaired cardiac activity , decrease in body temperature, decrease in heart rate, decrease in diuresis.
If timely medical care is not provided, death is possible as a result of vascular insufficiency, respiratory paralysis or pulmonary edema.
Long-term use of drugs containing bromine can lead to bromine poisoning, which is characterized by such symptoms: confusion, ataxia, apathy, depressed mood, conjunctivitis, colds, acne or purpura.
Treatment. Cases of acute poisoning with Valocordin should be treated in the same way as poisoning with other hypnotics and barbiturates, depending on the severity of the symptoms of poisoning. The patient must be admitted to the intensive care unit. Respiration and circulation require stabilization. Respiratory failure requires artificial respiration, shock is stopped by the introduction of plasma and plasma substitutes. If a lot of time has passed after taking the drug, it is necessary to wash the stomach (10 g of activated carbon powder and sodium sulfate are injected into the stomach). In order to quickly remove barbiturate from the body, forced diuresis with alkalis, as well as hemodialysis and / or hemoperfusion, can be performed.
Treatment of bromine poisoning: the removal of bromine ions from the body can be accelerated by the introduction of a significant amount of table salt solution with the simultaneous administration of saluretic agents.
If hypersensitivity reactions occur, prescribe desensitizing drugs.
Release form:
Drops Valocordin for oral administration, in dropper bottles of 20 and 50 ml.
Drops Valokrdin-Doxylamine drops 25 mg / ml: 20 or 50 ml in a vial.
Storage conditions:
Store in original packaging at a temperature not exceeding 25 °C.
Best before date- 5 years.
Conditions for dispensing from pharmacies - dispensed without a prescription.
1 ml Valocordin drops for oral administration contains:
- ethyl ester of bromisovaleric acid - 2%;
- phenobarbital -2%;
- peppermint oil - 0.14%;
- hop oils -0.02%;
- a mixture of ethyl alcohol - 96%;
- distilled water - up to 10%.
What is Valocordin
According to the accepted medical classification, Valocordin drops are sedative (sedative) drugs. Additionally, it can be used as an antispasmodic, because it relaxes the smooth muscles of the internal organs. The drug has a complex composition - phenobarbital and ethyl bromisovalerianate are declared as active substances.
Composition and form of release
From the instructions for use attached to each bottle, you can find out the detailed composition of Valocordin in drops:
Valocordin action
In small doses, the active substances of the composition have a sedative and hypnotic effect, in high doses they have a narcotic effect. Phenobarbital is a derivative of barbituric acid, inhibits the inhibitory system of the reticular formation, is able to slightly lower blood pressure. The substance is absorbed in the stomach, 35% of the dose binds to plasma proteins, the rest is filtered in the kidneys.
Reabsorption of phenobarbital occurs at a low level of acidity, and reverse diffusion is impossible due to the alkalinity of urine. 30% of the substance is excreted in the urine, part is oxidized in the liver. Prolonged use of the drug leads to the accumulation of the substance in the plasma, liver enzymes are induced. This leads to an acceleration of the oxidation process of phenobarbital.
Ethyl bromisovalerianate has sedative and antispasmodic properties, acts like a phenobarbital synergist, that is, it provides a rapid onset of effectiveness. The substance releases boron in the body, which is slowly excreted from the body. Long-term use of the drug threatens with chronic boron intoxication. Peppermint and hop oils have reflex, vasodilating and antispasmodic effects.
Indications for use
The main purpose of using the medication is to eliminate the violation of falling asleep. In addition, indications for the use of the drug are:
- insomnia, cardiovascular cardialgia;
- sinus tachycardia, neurotic conditions;
- pain in the heart, ischemia of the heart muscle;
- vegetative lability, increased irritability;
- hypochondriacal syndrome;
- early stages of arterial hypertension;
- spasm of the muscles of the gastrointestinal tract (intestinal, biliary colic);
- anxiety caused by psychosomatic phenomena;
- brain disorders, neuroses, accompanied by a sense of fear.
Indications for use
Tablet forms of the drug are used for the symptomatic treatment of conditions associated with sleep disorders.
The drug is widely used to treat conditions associated with a disorder in the onset and maintenance of sleep.
The drug is prescribed for diseases:
- neuroses of various etiologies;
- mental disorders accompanied by a sleep disorder;
- sleep disturbance associated with a change in time zone or work schedule;
- asthenic syndrome;
- allergic manifestations;
- stressful conditions;
- itching of the skin.
Tablets are used for the complex treatment of colds and coughs. In this situation, the drug helps to calm the nervous system, thus relaxing the patient so that he recovers faster.
How long does Valocordin work?
Doctors note that the drug begins to act very quickly. This is due to the immediate absorption of active ingredients from the stomach. When taken on an empty stomach, the properties of Valocordin begin to unfold after a few minutes. Similarly, side reactions are quickly observed with individual intolerance, therefore, during treatment, it is worthwhile to carefully monitor the patient.
In the early stages of hypertension, Valocordin can be used to reduce pressure. It dilates blood vessels, relieves spasms, increases the clearance between the vascular walls. At low pressure, the medication should not be used, as it can aggravate the patient's condition and lead to critical symptoms if the recommended dosage is exceeded.
Overdose
Symptoms of an acute overdose of barbiturates are dizziness, fatigue, deep sleep (it is difficult to wake the patient), swelling of the face, rash, itching. Severe poisoning is manifested by tissue hypoxia, coma, palpitations, arrhythmia. Vascular collapse may occur, reflexes may be lost. Left untreated, pulmonary edema or respiratory paralysis develops, leading to death. Prolonged use of Valocordin leads to bromine poisoning, manifested by confusion, ataxia, apathy, depression, colds and acne.
Treatment of an overdose is to stabilize and normalize breathing, blood circulation in a hospital. The patient is given artificial respiration, the shock is eliminated by the introduction of plasma substitutes. For gastric lavage, activated charcoal and sodium sulfate are used. You can carry out forced diuresis, hemodialysis, hemoperfusion. Accelerates the excretion of bromine table salt solution with saluretic agents. In hypersensitivity reactions, antihistamines are indicated.
The composition and action of the drug Valocordin
This medicine was created in the middle of the last century in Germany. Its unique action is based on the fact that it organically combines strong sedatives that have been used in medicine for many centuries.
1. "Phenobarbital" is an effective sleeping pill. It is used as an anticonvulsant and relaxing agent. It dilates blood vessels well, so it can be used for increased pressure, spasms and fear. In many countries, phenobarbital is considered a drug and banned from use. But a small amount of it in the composition of the drug "Valocordin" produces only a positive effect.
2. Ethyl ester of isovaleric acid is obtained from a medicinal plant, therefore it retains all its beneficial properties. Like valerian, this substance has a sedative, hypnotic and antispasmodic effect. It is these two components that determine the effect that the drug "Valocordin" has. Indications for use are directed mainly to the treatment of heart failure.
3. The composition of this drug also includes mint and hop oils, which have a sedative, vasodilating and antispasmodic effect. The combination of all these components creates the complex sedative effect that Valocordin has.
Instructions for use
The drug is able to enhance the effect of other sedatives, as well as weaken the effect of CNS stimulants, this is indicated by the instructions for use for the drug "Valocordin" (drops). The doctors' comments also note that phenobarbital, which is the active substance of the drug, weakens the effect of oral contraceptives, as well as glucocorticosteroids.
"Valocordin" is recommended to be taken before meals, diluting it with a small amount of purified water. The usual dose for an adult is 15 to 20 drops three times a day. The daily dose of the drug "Valocordin", the indications for the use of which mark its ability to fight insomnia and sleep disorders, can be increased to 30 drops. For children under the age of 12 years, the dosage of the drug is determined at the rate of one drop per one year of life. The duration of the course of treatment and the frequency of taking the medicine by children is determined by their attending physician, taking into account medical indications.
Interaction
With the simultaneous use of Valocordin
with sedatives - increased effect. Simultaneous use with neuroleptics and tranquilizers enhances, and with CNS stimulants - weakens the effect of each of the components of the drug. Alcohol enhances the effects of Valocordin
and may increase its toxicity. The presence in the composition of Valocordin
phenobarbital can induce microsomal liver enzymes, and this makes it undesirable to use it simultaneously with drugs that are metabolized in the liver, since their concentration, and therefore efficiency, will change as a result of a more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides). Phenobarbital weakens the effect of coumarin derivatives, corticosteroids, griseofulvin, oral contraceptives.
What is the danger of Valocordin
Many patients take Valocordin to reduce blood pressure or normalize sleep without a doctor's prescription. Is it really so safe? The drug is able to bring the body not only benefit, but also harm. More often, the side effects of Valocordin are due to improper use of the drug or the individual characteristics of the patient.
Once in the body, phenobarbital promotes the synthesis of microsomal enzymes in the liver. Against this background, other medications taken, metabolized in the liver, do not have the proper therapeutic effect.
Phenobarbital, which is part of the drug, refers to narcotic substances, is prohibited in some countries. With strict adherence to the dosage, this component does not cause negative consequences. If the doctor's recommendations are violated or the drug is taken for too long, there is a risk of addiction, a violation of the functioning of the central nervous system, or the development of a withdrawal syndrome.
In addition, the drug can affect concentration and memory. After taking it, it is forbidden to drive vehicles and operate potentially dangerous mechanisms.
A serious threat to human life and health is such a combination as Valocordin and alcohol. Ethyl alcohol enhances the narcotic effect of phenobarbital, therefore, against the background of taking alcoholic beverages, the use of Valocordin becomes extremely dangerous.
Analogues
There are a large number of drugs that are similar in composition and therapeutic effect to the drug in question. Analogues of Valocordin can be as follows:
- homeopathic drops of Knott - used for insomnia and excessive excitability of the central nervous system. The tool has a relaxing effect, normalizes the heart rhythm;
- Cavinton tablets - are used as a vasodilator, help to improve the supply of oxygen to the brain, help to utilize excess glucose. Assign a remedy to patients with disorders of a neuralgic and mental nature due to circulatory disorders of the brain;
- Sibazon tablets - eliminate spasm, have a relaxing effect, help get rid of convulsions, restore heart rhythm. Sibazon belongs to a number of psychotropic drugs;
- Corvalcaps capsules - are prescribed to overcome excessive nervous excitability, normalize sleep, lower blood pressure. Among the indications for use are insomnia, neuroses, conditions accompanied by spasm of the coronary vessels, intestinal spasms.
Valoserdin is a popular analogue of Valocordin
Special attention should be paid to such an analogue as Valoserdin. Often patients compare these two drugs, they are interested in which is better and what is the difference between these drugs? Valoserdin is a Russian drug, Valocordin is a German drug
In terms of their therapeutic effect, both drugs are identical. Their difference is in composition and cost. Valoserdin contains oregano oil, Valocordin does not. Valoserdin costs almost half as much as the German remedy.
Mechanism of action
The active substance leads to inhibition of the activity of the nervous system, eliminates the spasm of blood vessels, thus causing sleep.
The tableted agent does not have a pronounced therapeutic effect, since it is not used in the treatment of diseases of the heart and blood vessels. The drug is intended to reduce negative symptoms in case of nervous disorders and improve the general condition of the patient.
The active components of the drug can lead to a decrease in blood pressure, so taking the drug is contraindicated in hypotensive patients. In some situations, specialists prescribe tablets for the complex treatment of arterial hypertension to smoothly lower blood pressure levels.
special instructions
If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.
The drug contains 55 vol.% ethanol (the absolute content of ethanol in the maximum single dose (30 drops) is 0.469 g) and phenobarbital, so Valocordin
even when used correctly, it can impair the ability of patients to respond quickly in certain situations, such as while outdoors or while servicing cars. This is especially pronounced with the simultaneous intake of alcohol.
With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning.
Side effects
In case of non-compliance with the dosage of the drug, the following disorders develop on the part of organs and systems:
- Nervous system (headache, dizziness, drowsiness, seizures).
- Violation of the function of the visual apparatus (increased intraocular pressure).
- Disturbances in the work of the circulatory system (palpitations, decreased pressure, hypertension, disturbances in the work of the heart).
- Respiratory dysfunction (bronchial obstruction, bronchospasm)
- Digestive tract (dryness of the mucous membranes of the mouth, stool disorder in the form of constipation and diarrhea, pain in the stomach).
The selection of the dosage on an individual basis can reduce the risk of complications in the elderly.
Reception features
After taking the pill, it is necessary to ensure the normal duration of sleep, which is 7-8 hours, which will reduce the risk of a decrease in psychomotor reactions upon awakening.
Effervescent tablets must first be dissolved in water.
Rules to be followed during the therapeutic course:
- Avoid abrupt changes in body position, as this can slow down reactions.
- During the course of treatment with valocordin, it is not recommended to drink alcoholic beverages.
- Women during lactation while taking the medicine should stop breastfeeding, and transfer the child to artificial feeding for the entire period of treatment.
- The drug reduces the reaction rate, so it is contraindicated to go out and drive vehicles that require concentration.
- Tablets should be taken with plenty of liquid 60 minutes before bedtime.
special instructions
When taking Valocordin, you need to pay attention to some indications of the instructions. Excerpts from the Special Instructions:
the drug reduces the concentration of attention and the speed of psychomotor reactions, therefore, during the period of treatment, you should be careful when driving a car and operating mechanisms; if pain in the heart area does not go away after taking the medicine, consult a doctor to exclude the risk of acute coronary syndrome; the drug is used with caution in hyperkinesis, hyperthyroidism, adrenal hypofunction, heart failure, severe arterial hypotension, persistent pain, acute drug intoxication; long-term therapy with Valocordin is not recommended due to the risk of developing drug dependence, accumulation of bromine and the development of poisoning with this substance
Analogues
Corvaldin is an analogue of Valocordin in terms of active ingredients.
According to the mechanism of action, Valocordin has a large number of analogues in various dosage forms:
- Valerian tincture;
- Elixir - Klosterfrau Melisana;
- Tablets - Bromisoval, Corvalol, Valdispert, Valerian Forte, Valerian, Dormiplant, Potassium bromide, Bromocamphor, Simpatil, Novo-Passit, Patrimin, Songa night;
- Drops for oral administration - Valemidin, Valeodicramen, Valerianahel, Valocormid, Doppelherz Melissa, Corvalol, Notta, Passidorm;
- Oral solution - Valeran, Novo-Passit;
- Solution for injection - Litonite.
Before using analogues, consult your doctor.
Valocordin tablets and alcohol
Concurrent use of the drug with alcohol increases its toxic effect on the liver.
Ethanol negatively affects the functional ability of cells of the nervous system
Simultaneous use of the drug with alcoholic beverages can cause the following symptoms:
- dizziness;
- tachycardia;
- speech disorder;
- violation of motor activity;
- drowsiness;
- coma.
To avoid complications, alcohol can be consumed 4-5 days after the use of the drug.
Regular use of the drug can be addictive, in connection with which the patient constantly increases the therapeutic dose of the drug.
Valocardin in tablet form is used to treat nervous conditions that cause sleep disorders. The mild effect of the drug allows you to normalize falling asleep and deepen the sleep phases. However, overdose may cause complications, so the dose is selected individually for each patient, subject to all recommendations.
What everyone should know
- Prolonged uncontrolled use of the drug in excess of the prescribed dose can lead to addiction due to addiction to phenobarbital and chronic bromine poisoning - bromism. Bromine released from ethyl bromisovalerianate accumulates in the body, gradually causing intoxication. Manifestations of bromism: gastrointestinal disorders, bronchitis, rhinitis, conjunctivitis, acne, apathy, confusion, depression, speech and sleep disorders, memory impairment and other neurological disorders.
- With a sharp cessation of taking drops after their prolonged use, an abstinence syndrome develops - a withdrawal syndrome.
- The tool is incompatible with alcohol, which enhances its effect and increases toxicity.
- It is undesirable to combine drops with tranquilizers, antipsychotics, sedatives. The latter enhance the action of Valocordin, and the former weaken it. Thus, you can get the opposite effect to the expected one.
- Do not take drops before driving a car, because they cause slight lethargy, a decrease in the speed of psychomotor reactions.
Trade name:
Valocordin ®
International non-proprietary or grouping name:
phenobarbital + ethyl bromisovalerianate
Dosage form:
tablets
Composition per 1 tablet
active substances:
phenobarbital - 7.544 mg
ethyl bromisovalerianate - 7.544 mg
Excipients: peppermint leaf oil - 0.529 mg; hop common seed oil - 0.074 mg; beta-cyclodextrin in terms of dry matter - 55.550 mg; potato starch - 13.589 mg; lactose monohydrate - 43.770 mg; cellulose microcrystalline type 101 - 10.500 mg; calcium stearate - 0.900 mg.
Description:
Round, flat tablets with a beveled white or almost white color, interspersed with an embossed "V" marking on one side, smooth on the other side.
Pharmacotherapeutic group:
sedative.
ATC Code:
Pharmacological properties:
Pharmacodynamics
Combined drug, the action of which is due to the pharmacological properties of the components that make up its composition.
It has a sedative and antispasmodic effect.
Phenobarbital has a sedative (in low doses), hypnotic, muscle relaxant and antispasmodic effects. It helps to reduce the excitation of the central nervous system and facilitates the onset of sleep, enhances the sedative effect of another active substance.
Ethylbromisovalerianate has a sedative (similar to the effect of valerian) and antispasmodic effect, mainly of the receptors of the oral cavity and nasopharynx, due to irritation, a decrease in reflex excitability in the central parts of the nervous system and an increase in inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and direct local antispasmodic action on smooth muscles.
Pharmacokinetics
Data on the pharmacokinetics of ethyl bromisovalerianate are not available.
When taken orally, phenobarbital is absorbed slowly, completely. The maximum concentration in blood plasma is determined after 1-2 hours, the connection with plasma proteins is 50%, in newborns - 30-40%. Metabolized in the liver, induces microsomal liver enzymes by CYP3A4, CYP3A5, CYP3A7 isoenzymes (the rate of enzymatic reactions increases 10-12 times). accumulates in the body. The half-life is 2-4 days. It is excreted by the kidneys in the form of glucuronide, about 25% - unchanged. Penetrates into breast milk and through the placental barrier.
Indications for use
As a symptomatic sedative in functional disorders of the cardiovascular system, in neurosis-like conditions, accompanied by increased irritability, sleep disturbance, tachycardia, a state of excitation with pronounced vegetative manifestations.
Contraindications
Hypersensitivity to the components of the drug, acute hepatic porphyria, hereditary lactose intolerance, glucose-galactose malabsorption, age up to 18 years (efficacy and safety have not been established), severe renal and / or liver dysfunction, pregnancy and breastfeeding.
Carefully
Impaired kidney and / or liver function; simultaneous use with drugs that are metabolized in the liver (see section "Interaction with other drugs").
If you have one of the listed diseases/conditions, be sure to consult your doctor before taking the drug.
Use during pregnancy and during breastfeeding
The use of the drug during pregnancy and during breastfeeding is contraindicated, since phenobarbital crosses the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn.
Phenobarbital passes into breast milk. Perhaps the development of physical dependence in newborns.
If necessary, the use of the drug during lactation, breastfeeding should be discontinued.
Dosage and administration
Inside, before eating, drink plenty of water.
Adults: 1-2 tablets of the drug 2 times a day. With tachycardia, a single dose can be increased to 3 tablets.
The maximum daily dose is 6 tablets.
The dosage and duration of the drug is set by the doctor individually for each patient.
If necessary, please consult your doctor.
Side effect
Drowsiness, dizziness, slow heart rate, reduced ability to concentrate, allergic reactions. Gastrointestinal disorders may occur. These phenomena disappear with a decrease in the dose of the drug. With prolonged use of the drug, the development of drug dependence, addiction, "withdrawal" syndrome, as well as the accumulation of bromine in the body and the development of bromism (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements) are possible.
Very rarely, hypersensitivity reactions (shortness of breath, angioedema, severe adverse skin reactions) may occur.
Reports have been received: reduced bone mineral density; about the development of osteopenia and osteoporosis; about fractures in patients taking phenobarbital for a long time. The mechanism of the effect of phenobarbital on bone metabolism has not been identified.
If you have side effects indicated in the instructions for use; or they get worse; or you notice any other side effects not listed in the instructions, you must inform your doctor.
Overdose
Symptoms:
Depression of the central nervous system, nystagmus, ataxia, lowering blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
In severe cases - coma, accompanied by tissue hypoxia, respiratory failure, tachycardia, arrhythmia, vascular collapse, decreased peripheral reflexes.
Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy. With depression of the central nervous system - caffeine, nikethamide.
There is no specific antidote.
Interaction with other drugs
Medicines that depress the central nervous system enhance the effect of the drug.
Ethanol enhances the effect of the drug.
Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, lamotrigine, thyroid hormones, doxycycline, chloramphenicol, antifungal drugs (azole type), antibiotics, sulfonamides, griseofulvin, glucocorticosteroids and oral contraceptives) .
The drug can increase the toxicity of methotrexate.
The effect of the drug is enhanced by the use of valproic acid. If you are using any of the above or other medicines (including over-the-counter medicines), consult your doctor before using Valocordin®.
special instructions
Before using the drug, you should consult with your doctor.
There is no experience of using the drug in children under 18 years of age.
With uncontrolled use of the drug, drug dependence may occur.
During the use of the drug should not drink alcohol.
Influence on the ability to drive vehicles, mechanisms
When using the drug, you should avoid potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (including driving, working with moving mechanisms).
Release form
Tablets 7.544 mg + 7.544 mg
10 tablets in a blister pack.
1, 2, 3, 5 blister packs, together with instructions for use, are placed in a cardboard pack.
Storage conditions
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children.
Best before date
2 years.
Do not use after the expiration date.
Holiday conditions
Released without a prescription.
Marketing Authorization Holder / Consumer Claims Receiver:
Krevel Moizelbakh LLC, Russia, 115114, Moscow, Letnikovskaya street, 10, building 4, floor 7, room I, room 39g.
Manufacturer:
JSC "Usolye-Siberian Chemical and Pharmaceutical Plant"
665462, Irkutsk region, city of Usolie-Sibirskoe, north-western part of the city, from the north-east side, 115 m from the Baikal highway.
Valocordin- a combined sedative drug, the therapeutic effect of which is due to the pharmacological properties of the components that make up its composition. Phenobarbital has a sedative and mild hypnotic effect.
It helps to reduce the excitation of the central nervous system and facilitates the onset of natural sleep. Ethylbromisovalerianate has a sedative, hypnotic and antispasmodic effect.
Indications for use:
Drops Valocordin it is recommended to take with functional disorders of the cardiovascular system (including cardialgia, sinus tachycardia); neurosis, accompanied by irritability, anxiety, fear; insomnia (difficulty falling asleep); states of excitation, accompanied by pronounced vegetative reactions.
Mode of application:
Valocordin taken orally, before meals, with a small amount of liquid.
The dose is set individually.
Adults are usually prescribed 15-20 drops 3 times a day.
In case of disturbed falling asleep, the dose can be increased to 30 drops.
The duration of the drug is set individually by the doctor.
Side effects:
Valocordin, as a rule, is well tolerated even with prolonged use. In some cases, drowsiness and slight dizziness may occur during the daytime.
With prolonged use of large doses, chronic bromine poisoning may develop, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
Rarely, skin reactions may occur with hypersensitivity.
If you experience any side (unusual) effects that are not reflected in the instructions, you must report them to your doctor.
Contraindications:
Contraindications to the use of the drug Valocordin are: hypersensitivity to any of the components of the drug; severe impairment of kidney and / or liver function; pregnancy, lactation, children under 18 years of age.
With caution: liver disease, alcoholism, traumatic brain injury, brain disease. the preparation contains ethanol.
Pregnancy:
Take drops during pregnancy Valocordin contraindicated.
Interaction with other drugs:
With the simultaneous use Valocordina with sedatives - increased effect. Simultaneous use with neuroleptics and tranquilizers enhances, and with stimulants of the central nervous system - weakens the effect of each of the components of the drug. Alcohol enhances the effects of Valocordin® and may increase its toxicity. The presence of phenobarbital in Valocordin® can induce microsomal liver enzymes, and this makes it undesirable to use it simultaneously with drugs that are metabolized in the liver, since their concentration and, accordingly, the effectiveness will change as a result of a more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides and etc.)
Phenobarbital weakens the effect of coumarin derivatives, glucocorticosteroids, griseofulvin, oral contraceptives.
Overdose:
With mild and moderate intoxication, drowsiness, dizziness, psychomotor disturbances are observed.
In severe cases - coma, lowering blood pressure, respiratory failure, tachycardia, vascular collapse, decreased peripheral reflexes.
Treatment: gastric lavage, take activated charcoal and urgently call a doctor.
Storage conditions:
Store in a place protected from light, at a temperature of 15 ° C to 25 ° C.
Keep out of the reach of children.
Release form:
Valocordin - drops for oral administration.
20 ml, 50 ml in brown glass bottles with a dropper.
Compound:
1 ml of the drug Valocordin contains active substances: phenobarbital - 18.40 mg, ethyl bromisovalerianate - 18.40 mg.
Excipients: mint oil - 1.29 mg, hop oil - 0.18 mg, ethanol 96% - 469.75 mg, purified water - 411.97 mg.
Additionally:
If necessary, the prescription of the drug Valocordin during lactation, the issue of stopping breastfeeding should be resolved.
The drug contains 55 vol% ethanol (the absolute content of ethanol in the maximum single dose (30 drops) is 0.469 grams) and phenobarbital, so Valocordin®, even when used correctly, can weaken the ability of patients to respond quickly in certain situations, such as when being outside or when servicing cars. This is especially pronounced with the simultaneous intake of alcohol.
With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning them.
