Unsuccessful eco. When can I try again after unsuccessful IVF? How many times is it possible to do in vitro fertilization free of charge under compulsory medical insurance?

Today, for many women, IVF has become a real miracle, an opportunity to experience the joy of motherhood in spite of fate. But a miracle doesn’t always happen the first time. Often a second IVF attempt is required, sometimes a third, fourth... Let's try to figure out what to do in such a situation.

IVF is often talked about as a magical procedure that provides a 100% guarantee of pregnancy. Such an illusion can be extremely dangerous, because IVF is far from effective.

Even in Europe and America, in professional clinics equipped with the best and most modern equipment, the chance of getting pregnant after the first IVF attempt is 50-55%. In Russia, the effectiveness of IVF is still less and is about 30-50%.

Potential mothers are scared to think about such numbers, but these are official statistics.

Reasons for unsuccessful IVF

According to statistics, about half of IVF attempts (protocols) are unsuccessful. There can be many reasons for this, but most often we're talking about about the following factors:

• Immune. Immunity, which is usual time protects a woman’s body from external dangers, sometimes becomes an enemy. If he is excessively aggressive, he perceives the implanted egg as foreign body and rejects it.

• Alloimmune. The coincidence of some proteins of the parents can lead to an inadequate response immune system mother. This often becomes the reason for termination of pregnancy in consanguineous marriages.

• Blood clotting. High blood clotting can lead to embryo rejection. An indicator of increased coagulability can be varicose veins and enlarged hemorrhoids.

• Hormonal disbalance. Some hormonal parameters are not checked for the first IVF attempt, but may affect its effectiveness.

• Condition of the endometrium. Density, thickness, blood supply and some other factors characterizing the endometrium significantly affect the likelihood of embryo implantation and pregnancy maintenance.

• Ovarian response to stimulation. It is not always sufficient.

• Quality of eggs, sperm and embryos. Their ability to conceive depends on a lot of factors, including the qualifications of the doctor.

• Hidden infections.

And these are only some of the factors that can cause IVF failure. This does not mean that the second attempt will be just as unsuccessful, but mandatory preliminary diagnosis is required.

Diagnosis after IVF

Most women undergo a very extensive examination before the first protocol. But it is impossible to check all indicators and potential threatening factors, therefore, after unsuccessful IVF, a new examination is required, taking into account the current circumstances.

It is difficult to say what factors will need to be checked in each special case An individual scheme is developed, but in most cases the following studies are required:

• Endometrial examination. For this purpose they can be used different methods(ultrasound, hysteroscopy, biopsy, etc.). An additional study is Doppler ultrasound, which determines the quality of blood supply to the pelvic organs.

• Blood test for hormonal status, determination of immune factors.

• In-depth determination of blood clotting factors.

• Bacteriological culture to determine possible hidden infections.

If repeat IVF is required, the examination will help determine possible reasons failure of the first. In this case, appropriate treatment will be required to prepare the body for the new protocol.

Recovery after the protocol

If your first IVF didn't work out, you may need to put in some effort to prepare for a new protocol. The preparation time can vary quite a lot, depending on the situation, the results of the first and additional examination. The minimum break is 2-3 months. This period is necessary for the ovaries to recover after stimulation, and for the body to calm down after the stress that IVF is.

Methods of physiological and non-traditional therapy give a good effect: therapeutic baths, mud therapy, reflexology, acupressure, hirudotherapy. Complex vitamins can be used as medicinal support. Of course, both the first and second should be carried out under the supervision and with the permission of a doctor.

Many women ask how long IVF can be done. Doctors say the protocols themselves do not have any significant detrimental effects on health. No one can say exactly how many attempts will be required. There are many cases when you have to make 8-9 attempts to successfully conceive, but not all of this is uncommon.

If 3-4 attempts are unsuccessful, you can consider alternative options, for example, the use of donor eggs and sperm. This will help avoid problems associated with incompatibility and hereditary diseases.

Psychological aspect

Perhaps, unsuccessful IVF affects not so much the woman’s physiological health, but psychological state. For many women, it was an opportunity to get pregnant against fate. Often months of preparation are preceded by years of unsuccessful attempts to conceive on their own, numerous studies and long, unpleasant treatment.

In such a situation, unexpected periods after unsuccessful IVF become the collapse of hopes. Many women become depressed. This condition can be expressed by apathy, reluctance to do anything, irritability, decreased or lack of libido, numerous accusations against doctors and oneself.

At this moment, it is necessary to understand that a single attempt does not guarantee a result, that you can do repeated IVF, which will be more effective and bring a long-awaited pregnancy. In fact, there are only a few diseases that make such conception impossible; doctors have already learned to cope with most others.

Psychological and emotional support from loved ones is very important. First of all, the husband should provide it, but relatives and friends should not stand aside.

When conducting artificial insemination, it is not always possible to get pregnant the first time. If this does not work, a second IVF attempt is made. Repeated embryo transfer will be successful, subject to a scrupulous analysis of the previous failure and additional examination.

Reasons for failure

Despite careful preparation for the procedure, no one gives a complete guarantee of a positive outcome. The first embryo transfer is rarely successful, but the chances of a second IVF attempt increase significantly. Repeated fertilization does not harm the patient’s health and is absolutely safe.

The main ones can be:

• pathological condition of the endometrium - chronic endometritis, presence of polyps, thinning;
• negative changes in fallopian tubes ah, promoting ectopic embryo transfer;
• poor embryo viability;
• genetic problems;
• aggressive reaction of the mother's body to the embryo;
• disruptions in activity endocrine system and hormonal imbalance;
• the age of the expectant mother, especially if the woman is over 40 years old;
• poorly drawn up medical recommendations and unreliably conducted examinations.

Bad habits, chronic and infectious diseases, obesity and other factors have their negative impact.

In order to exclude a negative result when performing repeated IVF, it is necessary to take the future protocol more seriously, choose qualified specialist, strictly follow all instructions.

Rehabilitation after failure

A failed first artificial insemination is not a death sentence. Every female body has individual characteristics, and health needs time to recover. The second IVF attempt is not made immediately after the first; rest for at least two months, or a break for rehabilitation, is required. During this period, a woman has the opportunity to gather strength and restore psychological balance.

The following are recommended as restorative measures for the second attempt:

• the use of mud therapy, mineral baths;
• acupressure, hirudotherapy;
• taking vitamins as recommended by a doctor;
• physical activity - swimming, dancing, hiking, exercises that improve blood circulation in the pelvic organs are especially useful;
• conducting a repeated full examination, taking tests to eliminate the risk of failure;
• avoid stressful situations.

During the rehabilitation period and before undergoing IVF for the second time, a woman needs the support of her husband, close relatives and friends. In some situations, specialist help is required.

Repeated cryopreservation of embryos

If artificial insemination is unsuccessful, embryos frozen in liquid nitrogen are an additional chance in the desire to become a mother. The procedure is used as a 2nd IVF attempt in several special cases, for example, at the time of embryo transfer, the expectant mother fell ill with a viral infection.

The second transfer of frozen embryos is carried out after menstruation occurs, if the first attempt is unsuccessful. Further, in order to prepare the uterine mucosa for material transplantation, doctors prescribe taking various medicines containing female hormone.

When preparing the uterus to receive embryos, a hormonal analysis is performed to indicate its condition. If the parameters do not comply with the norm, the transfer is cancelled. Then, they wait for a new cycle, after which they can do repeated IVF.

Some future parents are worried about possible abnormalities in children born after a frozen embryo transfer. According to the research results, no pathologies in the child’s development were identified. The percentage of children born with any disorders using cryotransfer is no higher than the same figure for children conceived naturally.

Deadlines

After how long can you do a repeat eco? The timing of a new attempt at artificial insemination mainly depends on the recommendations of the attending physician and the desire of the woman. By coordinating these indicators, through certain time, you can do IVF, usually it takes 2-3 months. But, taking into account the individual characteristics of the body, only the doctor will determine when a second IVF attempt can be made, after two months or after a longer time.

But no specialist guarantees that second IVF attempts will be successful. Therefore, it is important, after each failure, to correctly determine the reasons that prevent pregnancy. But the inability to get pregnant for the first or second time is not a reason for despair. Many factors can be eliminated, and in half of the cases the woman carries and gives birth to a healthy child.

Only in difficult situations, after three unsuccessful attempts, doctors suggest taking other options. For example, the use of donor embryos, sperm or eggs. Sometimes it's only possible surrogacy. But before making a decision, you should not refuse to make another attempt at fertilization.

Modern medicine uses the latest techniques, and now almost every woman can become a mother. Everything should be seen as new level on the way to a successful pregnancy. At the next transplant, they are minimized negative factors previous procedures.

In vitro fertilization gives many families a chance to have a child. But there is no guarantee that you will get pregnant the first time. Even in countries with highly developed medicine, the primary procedure ends in birth only in 36-51% of cases. In Russia, the success rate of the first attempt is no more than 30%. But the second and subsequent ones give much more chances, up to 90%! Therefore, it is very important to determine how many times in a lifetime you can do IVF.

No one, not even the most experienced and eminent fertility doctor, can guarantee that you will be able to get pregnant after the first artificial insemination procedure. Unsuccessful attempts in this area are the rule rather than the exception. And there are many reasons for this.

The main reason for failure may be the age of the candidate. The older the woman, the less likely she is to become pregnant after IVF. The most favorable is up to 35 years of age. However, as when trying to get pregnant naturally, because with each month of life a woman’s number of follicles decreases. This increases the likelihood of a defective egg maturing.

From 35 to 40 years old, the chances of in vitro fertilization are still quite good - 25-40%. Success will depend on the number of follicles and the quality of the egg. But older age leaves a woman minimal chances. After 40 years, the possibility of a successful outcome is no more than 10%. Therefore, with age-related IVF, those are more successful.

There are other reasons unsuccessful attempt fertilization:

• disruptions in the hormonal system;
• bad habits;
• genetic diseases;
• infectious diseases;
• concomitant pathologies of the fallopian tubes and endometrium.

The woman’s gynecological history is important: have there been previous abortions, curettage, fibroids, inflammatory diseases, surgical operations. Other health problems, such as diseases of the liver, kidneys, gastrointestinal tract, heart, lungs, can also appear at the wrong time.

During the period of the artificial insemination procedure, the woman must be completely healthy so that the body does not waste energy fighting another disease. If you do not adhere to this principle, even a banal ARVI can become the cause of a failed pregnancy. Therefore, careful monitoring of well-being, test results, ultrasound and other studies is necessary.

The doctor’s qualifications and experience, as well as the woman’s correct adherence to his recommendations, can directly affect the positive outcome of an IVF attempt.

We cannot discount psychological reasons. After unsuccessful IVF, a woman may become depressed and lose hope for a favorable outcome. But a new protocol must be started with faith in success!

However, not everything depends on the woman. The reason for an unsuccessful protocol can be both the quality of the husband’s or donor’s sperm, and the quality of the implanted embryos.

How long after you can do repeat IVF?

To stimulate follicle growth, doctors use high doses hormonal drugs. The consequences of taking them can be expressed in:

• hair loss;
• deterioration of emotional state;
• weight fluctuations up or down;
• blood clotting disorders;
• problems with the thyroid gland;
• disruptions in the menstrual cycle, etc.

If you repeat IVF every cycle, hormonal therapy may end. Symptoms of OHSS appear 2-5 days after ingestion loading dose hormones. A woman experiences a bursting sensation in the ovarian area, and often a sharp stabbing pain. Decline blood pressure, tachycardia, nausea, vomiting, swelling of the arms and legs - these are just some of the symptoms that can torment a woman as a result of stimulation of hyperovulation. There have been cases of death due to OHSS.

To prevent this from happening side effect, reproductive specialists recommend taking breaks between attempts.

In case of failure, a repeat protocol should be started no earlier than after 3 months to give the body time to rest and recover. After all, if the next attempt is successful, expectant mother You will need strength to successfully bear and give birth to a child.

How many attempts can you make in a lifetime?

The number of IVF attempts is not regulated by Russian law. However, there is a WHO recommendation that the following in vitro fertilization It is unacceptable to carry out earlier than after three menstrual cycles. Thus, it is easy to calculate that it is recommended to make no more than 4 IVF attempts per year.

Deciding how often IVF can be done and how many protocols to carry out should be made individually, based on the causes of infertility, the patient’s age, the results of her tests and examinations.

If the patient is no more than 35 years old, she has a regular menstrual cycle and there are no problems with hormonal levels, may take place. This program is not as effective as classic in vitro fertilization, for the reason that doctors only observe natural processes in the body and do not have the opportunity to influence them.

Ideally, only one egg can be retrieved, which may not be suitable for fertilization. However, the fertilization program in the EC has one big advantage - it does not involve stimulating ovulation with hormonal drugs. Repeated attempts at a natural protocol cause much less harm to a woman’s health than, for example, repetitions of a short or long protocol. But even in this case, the artificial insemination procedure cannot be continued indefinitely.

Reproductionists around the world have an unspoken rule that you should stop trying IVF after the eighth failure. After the fifth protocol, each subsequent one has less and less chance of success, so it is not advisable to continue along the same path. Usually, a family dreaming of having a child is offered to change the artificial insemination program. For example, try using a donor egg. The oocyte (egg) donation program has a success rate of more than 55%.

There is a known case when a long-awaited pregnancy occurred only after 44 attempts!

How many times is it possible to do in vitro fertilization free of charge under compulsory medical insurance?

The order of the Ministry of Health on free IVF was issued in 2004. Since 2013, this opportunity has become publicly available. To date most of All artificial insemination procedures in Russia are carried out under the compulsory medical insurance policy. To get the opportunity to do IVF for free, you need to apply for a quota.

The IVF quota covers such stages as:

• stimulation of ovulation;
• egg retrieval and insemination;
• cultivation and cryopreservation (freezing) of embryos;
• intrauterine embryo transfer.

The IVF procedure under compulsory medical insurance is considered complete when an ultrasound detects a fertilized egg in the uterus.

Covers expenses up to 141,000 rubles. All medications necessary for the listed procedures are also paid for from the Compulsory Medical Insurance Fund. But tests and examinations before and after IVF are not included in the quota. If necessary donor egg or sperm, you will also have to pay for them yourself.

Absolutely any couple of Russian citizens, not necessarily married, and even a single woman, have the right to undergo IVF under compulsory medical insurance. Infertility, whether male or female, must be confirmed by examinations.

Theoretically, 3-4 attempts at in vitro fertilization can be made per year. But in practice it turns out differently. Preparing for IVF from the moment you consult a doctor until the embryo is transferred can take from several months to six months. The process is also complicated by the fact that the results of some tests are valid for only 14 days.

Although the legislation does not limit the number of attempts, in practice it turns out that you can do IVF for free only 1-2 times a year.

Embryos frozen from previous attempts can be used in subsequent attempts (cryoprotocol).

The demand for in vitro fertilization leads to the formation of queues for free procedure. Therefore, in case of an unsuccessful attempt, you must immediately join a new queue.

Unfortunately, none of the ART methods is a 100% guarantee of pregnancy. According to statistics, the success rate of IVF ranges from 30 to 60% depending on the patient’s age, the number and quality of the embryos obtained, as well as many other individual factors and the condition of the body. However, do not despair if the initial attempt is unsuccessful. You have every chance to achieve the desired result in a repeated protocol; the main thing is to analyze the reasons for failure and find the right approach.

Nowadays, the IVF procedure has become more accessible as a treatment method, more in demand and, to a certain extent, less dangerous, thanks to the accumulated knowledge and experience of reproductive specialists. More than 4 million children around the world have already been born thanks to IVF and other types of ART. In parallel with this, the level of clinics providing these services is increasing, and the range of programs and opportunities for conceiving a child in the most seemingly hopeless conditions is expanding.

Competent analysis of previous stimulation protocols, as well as subsequent stimulation of superovulation by an experienced reproductive specialist who regularly monitors general state patients and the ovarian response to stimulation - reduces the risks of complications to a minimum, and the effectiveness to a maximum.

Reasons for failure in IVF:

1. One of the most common reasons failure to get pregnant after IVF is the quality of the embryos. It depends both directly on the quality of gametes (oocytes and sperm) and on external factors, important of which are the level of equipment of the embryology laboratory, the qualifications and experience of embryologists, and the quality of the media used. Awareness of the patient about these parameters is important before making a decision in which clinic to conduct subsequent IVF attempts. Having its own genetic laboratory and full-time specialists - geneticists, urologists-andrologists, therapists, psychologists - is a big plus for an ART clinic, since only with an integrated and competent approach can the success of the procedure as a whole be ensured.

2. For successful implantation, the condition of the endometrium at the time of embryo transfer is important. The most a common question The patient’s question before the transfer is “has the endometrium grown well enough?” To date, there is no clear answer as to how large the endometrium should be before transfer. It is necessary to understand that the thickness of the endometrium is not as important as its timely transformation, structure and receptive activity. There is the concept of an implantation window - these are the days of your own or prepared cycle in which embryo implantation is most likely. Each woman has this window individually, and it is most promising to adhere to natural cycle. However, in its absence, a reproductologist will always “support” the endometrium with hormonal drugs, both in the first and second phases, and will also monitor the level of his own hormones, which will allow him to choose optimal time for embryo transfer. Independent and uncontrolled use of hormonal drugs can result not only in failure to achieve pregnancy, but also in serious health problems.

It is important before the IVF procedure to exclude infectious pathology of the endometrium - chronic endometritis. Chronic infections viral-bacterial origin, often asymptomatic, activate immunological reactions and disrupt local vascular processes in the endometrium, preventing embryo implantation and contributing to early pregnancy miscarriages. Experienced specialists performing a pelvic ultrasound can identify indirect signs of chronic endometritis. This assumption can only be confirmed by histological examination of the endometrium, the material for which can be obtained using outpatient pipell bopsy or hysteroscopy. The choice of one method or another depends on the presence of additional suspicions of endometrial pathology - polyps, endometrial hyperplasia, etc.

3. Pathological changes in the fallopian tubes - hydropyosalpinxes (overstretched fallopian tubes filled with liquid content) are sometimes the cause of unsuccessful IVF. Stimulation of the ovaries can provoke their growth and an increase in the source of infection, with all subsequent adverse consequences. The tactic of removing such pathological formations before the IVF procedure has successfully proven itself and is highly recommended, especially when preparing for repeated attempts.

4. Genetic problems.

Karyotyping of spouses - the study of the chromosome set - is one of the most important research, especially if the couple suffers IVF failures one after another. Pathological cryotype (different from 46XX in women or 46XY in men) can be the reason for failure to get pregnant. Carriage of certain chromosomal mutations in parents can negatively affect the offspring, therefore, if parents are aware of this pathology, preimplantation testing is recommended genetic diagnostics. The procedure for determining qualitative and quantitative changes in chromosome set embryo allows you to increase the chances of pregnancy up to 65%, and reduce the risks of early losses. At the Next Generation clinic, preimplantation diagnostics is carried out using the Array CGH method, which allows simultaneous diagnosis of all pairs of chromosomes in the embryo.

5. Endocrinological problems

One of the factors for the unsuccessful outcome of IVF can be diseases of the endocrine system. Consult an endocrinologist in advance and inform your fertility specialist about existing problems.

6. Immunological disorders

Long-term infertility and repeated failures in IVF can be caused by a number of immunological disorders. One of the most important may be the relationship between spouses at the level of histocompatibility antigens (the so-called HLA - human leucocyte antigen)

Normally, the incompatibility of spouses in terms of HLA antigens and the difference between the fetus and the mother’s body is important point necessary for maintaining and carrying a pregnancy. During the normal development of pregnancy, “blocking” antibodies to paternal antigens appear from the very beginning. early dates pregnancy and determine its normal course.

The similarity of spouses in histocompatibility antigens leads to the “identity” of the embryo to the mother’s body, which causes insufficient antigenic stimulation of the woman’s immune system, and the reactions necessary to maintain pregnancy are not triggered. The embryo is perceived as a foreign agent, which leads to the initiation of termination of pregnancy.

7. Excess weight.

Excess weight and obesity adversely affect all stages of the IVF procedure, the subsequent development and gestation of pregnancy. Consultation with a nutritionist and endocrinologist for overweight required before planning a protocol. Often, weight loss of even 5-7 kg leads to dramatic changes in IVF outcomes

8. Age.

The reason for unsuccessful IVF may be the age of the patient. In women over 40 years of age, the effectiveness of each subsequent attempt, unfortunately, drops sharply. The reason for this is age-related changes in the chromosomal apparatus of eggs. For such patients, we strongly recommend that during an IVF cycle, preimplantation chromosomal screening of embryos using the method of comparative genomic hydridization is carried out in order to detect and transfer only viable embryos into the uterine cavity. If there are none after the study, we are always ready to offer alternative programs using donor material.

Let's take a closer look at the benefits of a repeat IVF procedure at NGC in case of negative result previous attempt

• Stimulation of superovulation. Be sure to take the previous stimulation protocol with you. The clinic’s experienced reproductive specialists will analyze the possible causes of failure and select the most appropriate therapy. The pharmacy of our clinic is equipped with all the necessary drugs according to the most affordable prices. Storage conditions for medications are carefully monitored. The clinic's medical staff will always advise and teach you how to properly handle injectable medications, since timely and correct administration of medications ensures adequate maturation of follicles in the ovaries.
• Puncture. Correctly chosen puncture date is the most important component of success. Receiving immature or degenerate eggs, unfortunately, leads to the impossibility of their fertilization and failure of the program. The lion's share of success depends on the patient's discipline and strict adherence to the medical instructions of the attending physician. If additional explanation of the appointments, time, dosage and other features of the protocol is required, it is always worth asking clarifying questions to the doctor or medical staff of the clinic. Don’t be shy, an extra question is another step towards success!
• Fertilization. Our embryologists carefully care for each patient’s egg. Saving on media for fertilization and embryo cultivation is not our rule. To improve the effectiveness of ART programs, the board of doctors and embryologists of our clinic decided to use specialized environments for all groups of patients, which are used all over the world to overcome infertility in patients of advanced reproductive age.
• Embryo cultivation. Embryo cultivation in our clinic is carried out in incubators with a multi-gas mixture, which is a significant advantage compared to the use of CO2 incubators. We are proponents of transferring 5-day embryos. In addition, our doctors are unequivocal supporters of the transfer of only one embryo (SET-single embryo transfer).
• Embryo transfer. The most important stage IVF procedures. The doctor’s experience is of no small importance in this manipulation, as are the conditions under which the transfer is carried out. After embryo transfer, we recommend leading a normal, active, more moderate lifestyle, avoiding significant physical and emotional stress. However, we are not committed to bed rest after embryo transfer, nor to excessive administration medications(polypharmacy). All therapy after the transfer has its own rationale and is prescribed exclusively according to evidence-based medicine.

So, summing up this section, we recommend that our patients do not despair, but after analyzing the reason for the negative result, when trying IVF again, trust experienced reproductive specialists and believe in success, since a lot depends on your attitude and self-confidence!

The effectiveness of the in vitro fertilization procedure, according to statistics, after the first attempt does not exceed 30%. You should not expect 100% success, even if the procedure is carried out in the best foreign clinics. Unsuccessful IVF after the first attempt is not a death sentence. Several of them can be carried out. Next, we will try to understand the reasons that most often cause unsuccessful IVF.

Unsuccessful IVF: main reasons

• The main reason why IVF failures occur is the low quality of the resulting embryos. In order for the procedure to be successful, it is necessary to place into the woman’s uterine cavity those embryos that consist of 6-8 cells and also have high division rates. Poor-quality embryos can be obtained in situations where the embryologist’s qualifications are insufficient, or there are disturbances in male and female reproductive cells (eggs, sperm).
• Unsuccessful IVF can occur if there is any damage to the inner layer of the uterus (endometrium). Normally, for high-quality and successful attachment of the embryo in the uterine cavity, the presence of endometrium with a thickness of 7-14 millimeters is necessary. Most often, endometrial pathology, which is determined after unsuccessful IVF, is chronic endometritis, polyps, hyperplasia or thinning of the endometrium. All these disorders are quite easily diagnosed using ultrasound examination(ultrasound).
• Unsuccessful IVF may be a consequence of obstruction of the patient’s fallopian tubes, as well as the accumulation of fluid in them. This is a fairly serious pathology that requires treatment, most often surgically.
• Genetic disorders in one or both spouses can provoke a situation where IVF is unsuccessful.
• The presence of special antibodies in a woman’s body that prevent pregnancy from occurring even through artificial insemination.
• Hormonal imbalance in a woman's body. It has been scientifically proven that the entire process of egg maturation, their release from the ovaries during ovulation, fertilization, attachment (implantation) in the uterus and subsequent pregnancy are regulated by hormones. Which means any hormonal disbalance violates the integrity of this chain and leads to IVF failures.
• Availability bad habits both spouses. The harmful effects of alcohol, nicotine, narcotic substances has been proven for a long time and is not subject to any doubt.
• Age factor. How older age women undergoing IVF, the higher the risk that these IVFs will fail. The same applies to the partner whose sperm is used to fertilize the egg.
• Obesity is a problem that has serious overall impact on the woman's health status. It may be the reason that IVF is unsuccessful.
• Polycystic changes in the ovaries, leading to the fact that the quality of eggs decreases and it is much more difficult for sperm to fertilize them.
• Ovarian depletion, which occurs for some reason and leads to a decrease in follicular reserve. If a patient has such a pathology, it is very difficult to obtain high-quality eggs in the required quantity.
• Infectious diseases, such as herpes, mycoplasmosis, chlamydia, cytomegalovirus infection, Epstein-Bar infection, hepatitis B, C and others, increase the likelihood that IVF will fail.
• Adhesive processes that exist in a woman’s pelvis also lead to unsuccessful IVF attempts.
• The presence of acquired or congenital anomalies of the uterine structure in a patient (bicornuate or saddle-shaped uterus, uterine fibroids, etc.) can be a serious obstacle to pregnancy.
• Unsuccessful IVF may be a consequence of chronic somatic diseases gastrointestinal tract, of cardio-vascular system, respiratory system, as well as other organs and systems of the woman’s body.

In the case where even repeated IVF is unsuccessful, you need to more carefully look for the reason that leads to this.

Failed IVF: no periods

Each woman's body reacts differently to the in vitro fertilization program. If IVF has failed and there is no period, there is no need to panic. Most often recovery menstrual cycle occurs a few months after unsuccessful IVF. The reasons for the delay of menstruation after artificial insemination are those medicinal and invasive interventions in the woman’s body that were performed to stimulate superovulation, take eggs from the ovaries and introduce embryos into the uterine cavity. You should know that under no circumstances should you take hormones and other medications on your own if IVF has failed and you are not menstruating.

In addition to the absence of menstruation, there are also often copious discharge after artificial insemination. This phenomenon does not indicate serious problems, but is a consequence of taking various hormonal drugs. Sometimes patients after unsuccessful IVF note that menstruation is longer and more painful, which occurs due to the same stimulation of superovulation that is carried out before the IVF procedure.

Most often, the next menstruation will be the same as before IVF. If the restoration of menstruation has not occurred, then it is necessary to see a specialist.

Physiological pregnancy after unsuccessful IVF

There are statistics that show that more than 20% of partners who had an unsuccessful IVF program subsequently conceived a child naturally. This is explained by the fact that the IVF protocol involves taking various medications that seem to trigger a woman’s physiological hormonal cycle. Thus, the natural mechanisms of the woman’s reproductive system are activated.

Repeated IVF after failure

Before repeating IVF after an unsuccessful attempt, both partners must restore their physical and psycho-emotional health. For this you need adhere to special recommendations.

• Rest and rest until the next in vitro fertilization protocol. At this time, “light” sports (swimming, exercise, dancing, yoga, etc.) will help restore the body’s strength. Special attention It is advised to pay attention to those exercises that improve blood flow in the pelvic organs.
• Normal sex life, which does not have to be carried out according to a special schedule.
• Conducting additional examinations, taking tests, and performing procedures that will help identify the reasons that IVF was unsuccessful.
• Another way out of depression important factor, overcoming which, it is possible to carry out repeated IVF. After all, everyone knows that depression and stress significantly reduce the chances of success. During this period, the support of relatives, friends and significant other is extremely important. If this is not enough, then you need to seek help from a specialist (psychologist, psychotherapist).

Repeated IVF: how many attempts are allowed

According to experts, the in vitro fertilization protocol does not have any special effect negative influence on female body. The number of times repeat IVF can be performed must be determined individually and together with the attending physician. Cases have been described when successful IVF accounted for only the ninth procedure.

There is an opinion that after the third or fourth attempt, when IVF is unsuccessful, you need to think about other infertility treatment options. This may be the use of donor germ cells (eggs or sperm), ICSI fertilization or surrogacy.

At the Volgograd IVF Center clinic you can undergo a full examination and infertility treatment, including the use of IVF.